Action potential (AP) repolarization was tested in atrial preparations of adult NWR and SHR. Prolongation of pause interval interposed in the basic driving frequency of 2 Hz caused a shortening of the early phase and a prolongation of the final phase of repolarization in both NWR and SHR. AP's in SHR exhibited longer durations compared to NWR. However, at pause prolongation the relative increment of AP-duration at the 70% repolarization level (APD70) was less in SHR. This might indicate a positive correlation between electrical and mechanical restitution kinetics. The Na-Ca-exchange could be a possible link for an interpretation of this correlation.
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