This study evaluates the stress distribution in mandibular molar teeth with external cervical resorption restored using various restorative and biomimetic materials through finite element analysis. A mandibular first molar was scanned to create a 3D model. 'Class 2Bp' external cervical resorption defects were simulated on the buccal aspect and restored with different materials. Composite resin or highly viscous glass ionomer cement restored the coronal portion, while mineral-trioxide-aggregate, Biodentine, BioAggregate, or glass-ionomer cement filled the radicular portion. Models representing unrestored external cervical resorption and intact teeth were also created. Access cavities were restored with composite resin in all models except the intact tooth model. This computational simulation study used finite element analysis (ANSYS) to assess stress distribution in mandibular molars with external cervical resorption. A 300 N oblique force, directed buccally at a 45° angle, was applied to simulate masticatory forces, and von Mises stresses were evaluated in the resorption regions to compare materials' performance in terms of stress concentration and tooth integrity. Similar stress distributions were observed when restoring the coronal portion with composite resin or highly-viscous glass ionomer cement. Stress decreased with mineral-trioxide-aggregate or glass-ionomer cement in the radicular portion compared to Biodentine and BioAggregate. Restored and intact tooth models experienced lower stresses than unrestored tooth. All tested models were considered safe, except the unrestored external cervical resorption model. Restored external cervical resorption models are generally safe; however, using mineral-trioxide-aggregate or glass-ionomer cement in the radicular portion may slightly reduce stress in external cervical resorption regions.
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http://dx.doi.org/10.1007/s10266-024-01029-6 | DOI Listing |
Radiother Oncol
December 2024
Department of Radiation Oncology, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Homi Bhabha National Institute, Kharghar, Navi Mumbai, Maharashtra, India. Electronic address:
Background And Purpose: Knowledge-based planning (KBP) can consistently and efficiently create high-quality Volumetric Arc Therapy (VMAT) plans for cervix cancer. This study describes the cross-validation of two KBP models on geographically distinct populations and their comparison to manual plans from 67 centers. The purpose was to determine the universal applicability of a generic KBP model.
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December 2024
Institute of Biomedical Informatics, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Objectives: Muscle loss after radiotherapy is associated with poorer survival in patients with oral cavity squamous cell carcinoma (OCSCC). However, the threshold of muscle loss remains unclear. This study aimed to utilize explainable artificial intelligence to identify the threshold of muscle loss associated with survival in OCSCC.
View Article and Find Full Text PDFSci Rep
December 2024
Division of Clinical Research, Technological Development of the National Cancer Institute, Rio de Janeiro, Brazil.
This study investigates the changing epidemiological profile of tongue squamous cell carcinoma (SCC) to young patients, highlighting its rising incidence among non-traditional risk groups. A retrospective descriptive study was conducted, covering data from medical records between 2000 and 2012. Patients were categorised into two age groups (≤ 40 years; 41-50 years).
View Article and Find Full Text PDFHead Neck
December 2024
Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.
Background: Composite rhinectomy defects pose significant challenges due to the nose's complex structure and role in facial esthetics and function. Traditional nasal reconstructions often require multiple stages to restore mucosal lining, structural support, and external skin.
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Oncoimmunology
December 2025
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
The adenosinergic pathway converting endogenous ATP to adenosine (ADO) is a major immunosuppressive pathway in cancer. Emerging data indicate that plasma small extracellular vesicles (sEV) express CD39 and CD73 and produce ADO. Using a noninvasive, highly sensitive newly developed assay, metabolism of N-etheno-labeled eATP, eADP or eAMP by ecto-nucleotidases on the external surface of sEV was measured using high pressure liquid chromatography with fluorescence detection.
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