We developed a statistical theory of zero-count-detector (ZCD), which is defined as a zero-class Poisson under conditions outlined in this paper. ZCD is often encountered in the studies of rare events in physics, health physics, and many other fields where counting of events occurs. We found no acceptable solution to ZCD in classical statistics and affirmed the need for the Bayesian statistics. Several uniform and reference priors were studied, and we derived Bayesian posteriors, point estimates, and upper limits. It was shown that the maximum-entropy prior, containing the most information, resulted in the smallest bias and the lowest risk, making it the most admissible and acceptable among the priors studied. We also investigated application of zero-inflated Poisson and Negative-binomial distributions to ZCD. It was shown using Bayesian marginalization that, under limited information, these distributions reduce to the Poisson distribution.
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http://dx.doi.org/10.1097/HP.0000000000001883 | DOI Listing |
Chin Med
January 2025
Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Background: This research aims to explore the anti-obesity potential of Wu-Mei-Wan (WMW), particularly its effects on adipose tissue regulation in obese mice induced by a high-fat diet (HFD). The study focuses on understanding the role of heat shock factor 1 (HSF1) in mediating these effects.
Methods: HFD-induced obese mice were treated with WMW.
J Am Chem Soc
January 2025
P. Roy and Diana T. Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 S. 34th St., Philadelphia, Pennsylvania 19104, United States.
Photocatalytic C-H activation is an emerging area of research. While cerium chloride photocatalysts have been extensively studied, the role of alcohol additives in these systems remains a subject of ongoing discussion. It was demonstrated that the photocatalyst [NEt][CeCl] () produces •Cl and added alcohols exhibit zero-order kinetics.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Background: Fundamental questions remain about the key mechanisms that initiate Alzheimer's disease (AD) and the factors that promote its progression. Here we report the successful generation of the first genetically-engineered marmosets that carry knock-in (KI) point mutations in the presenilin-1 (PSEN1) gene that can be studied from birth throughout lifespan.
Method: CRISPR/Cas9 was used to generate marmosets with C410Y or A426P point mutations in PSEN1.
Alzheimers Dement
December 2024
University of Southern California, Los Angeles, CA, USA.
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