Worldwide, approximately 4.5% of adults identify as transgender or gender diverse (TGD), with up to 8.4% of youth identifying as TGD (Scheim et al 2024), suggesting that the number of TGD patients reaching reproductive age is increasing. Unfortunately, a major limiting factor to high quality reproductive health care for TGD people is lack of provider knowledge on gender-affirming treatments and reproductive needs unique to the TGD population (Korpaisarn and Safer 2018). Moreover, TGD individuals are still subjected to discrimination and mistreatment in the healthcare setting (Clark et al 2023). This special issue, a collection of 9 reviews and one survey study (Figure) aims to highlight unique considerations for reproductive health providers caring for TGD individuals and improve knowledge in this important area.
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http://dx.doi.org/10.1530/REP-24-0455 | DOI Listing |
Nat Commun
December 2024
Imperial College Parturition Research Group, Institute of Reproductive and Developmental Biology, Department of Metabolism Digestion and Reproduction, Imperial College London, London, UK.
Lactobacillus species dominance of the vaginal microbiome is a hallmark of vaginal health. Pathogen displacement of vaginal lactobacilli drives innate immune activation and mucosal barrier disruption, increasing the risks of STI acquisition and, in pregnancy, of preterm birth. We describe differential TLR mediated activation of the proinflammatory transcription factor NF-κB by vaginal pathogens and commensals.
View Article and Find Full Text PDFEcol Lett
January 2025
School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Offspring of older breeders frequently show reduced longevity, which has been linked to shorter offspring telomere length. It is currently unknown whether such telomere reduction persists beyond a single generation, as would be the case if germline transmission is involved. In a within-grandmother, multi-generational study using zebra finches, we show that the shorter telomeres observed in F1 offspring of older mothers are still present in the F2 generation even when the breeding age of their F1 mothers is young.
View Article and Find Full Text PDFFront Public Health
December 2024
Department of Clinical Pharmacy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Background: An essential part of aging is menopause, which indicates the final phase of the female reproductive cycle. The objective of this research was to assess anxiety and depressive symptoms among menopausal women in Asir region, Saudi Arabia.
Methods: The cross-sectional survey was carried out in February to June 2024, using a random sampling procedure, study participants were selected.
PNAS Nexus
January 2025
Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven - University of Leuven, Leuven 3000, Belgium.
Global seasonal influenza circulation involves a complex interplay between local (seasonality, demography, host immunity) and global factors (international mobility) shaping recurrent epidemic patterns. No studies so far have reconciled the two spatial levels, evaluating the coupling between national epidemics, considering heterogeneous coverage of epidemiological, and virological data, integrating different data sources. We propose a novel-combined approach based on a dynamical model of global influenza spread (GLEAM), integrating high-resolution demographic, and mobility data, and a generalized linear model of phylogeographic diffusion that accounts for time-varying migration rates.
View Article and Find Full Text PDFFront Glob Womens Health
December 2024
Department of Epidemiology and Public Health, School of Life Science, Central University of Tamil Nadu, Thiruvarur, India.
Background: In low-income countries, women with disabilities face numerous challenges in accessing sexual and reproductive health services and experience high unintended pregnancy rates and adverse pregnancy outcomes, with 42% of cases ending in abortion. However, little is known about unintended pregnancy among women with disabilities in Ethiopia. Therefore, this study aimed to assess the prevalence of unintended pregnancy and associated factors among women with disabilities in the Central Regional State of Ethiopia.
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