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Statin Use With Immune Checkpoint Inhibitors and Survival in Nonsmall Cell Lung Cancer.
Clin Lung Cancer
December 2024
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD.
Objective: To determine the association between concurrent statin use with immune checkpoint inhibitors (ICIs) and lung cancer-specific and overall mortality in patients with nonsmall cell lung cancer (NSCLC).
Materials And Methods: SEER-Medicare was used to conduct a retrospective study of Medicare beneficiaries ≥65 years of age diagnosed with NSCLC between 2007 and 2017 treated with an ICI. Patients were followed from date of first ICI claim until death, 1 month from last ICI claim, or 12/31/2018, whichever came first.
Intrinsic timing of brood care in shell-dwelling cichlids.
Curr Biol
January 2025
Max Planck Institute for Biological Intelligence, 82152 Martinsried, Germany. Electronic address:
Brood care relies on interactions between parents and offspring. Emergence of nestlings from their nest has been hypothesized to rely on the readout by the parent of the maturational state of the young. Theoretical considerations predict a conflict: parents should push for early emergence, if possible, to reduce care demands and maximize the number of reproductive cycles, whereas offspring should delay leaving to maximize resource allocation and protection by the parents.
View Article and Find Full Text PDFDownscaling global reference points to assess the sustainability of local fisheries.
Conserv Biol
January 2025
Thriving Oceans Research Hub, School of Geosciences, University of Sydney, Camperdown, NSW, Australia.
Multispecies coral reef fisheries are typically managed by local communities who often lack research and monitoring capacity, which prevents estimation of well-defined sustainable reference points to perform locally relevant fishery assessments. Recent research modeling coral reef fisheries globally has estimated multispecies sustainable reference points (i.e.
View Article and Find Full Text PDFIncreasing parent-child play frequency via exclusively online, video-based, peer-to-peer modeling program: randomized controlled trial.
Pediatr Res
January 2025
Division of Growth and Development, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Background: Equipping parents with play skills can foster child development. This study examined the effects of Power of Play Parent Intervention, a short, online, asynchronous, play skill enhancement program, on the frequency of total parent-child play, parents' attitude towards play, and children's screen time in Thailand.
Methods: From September to December 2023, 112 parents of children aged 12-36 months from social media platforms were block-randomized into two-arm, parallel groups (56 intervention and 56 waitlist control).
An improved SPWM control approach with aid of ant lion optimization for minimizing the THD in multilevel inverters.
Sci Rep
January 2025
Department of Electrical Engineering, Faculty of Engineering, Al-Azhar University, Cairo, Egypt.
This article presents an innovative asymmetric multilevel inverter (MLI) topology that outperforms conventional counterparts. The introduced topology presents a breakthrough in implementing power electronics control by maximizing specific levels while minimizing switching components. A cutting-edge control scheme for optimal operation of the cascaded half-bridge MLI is presented.
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