AI Article Synopsis
- The study investigates the role of the Small RNA Binding Exonuclease Protection Factor La (SSB) gene in lung adenocarcinoma (LUAD), assessing its expression levels and correlation with imaging parameters from F-FDG PET/CT scans.
- Fifty-five LUAD patients were analyzed using PET/CT imaging to measure metabolic parameters and compare SSB’s diagnostic value against the existing standard marker, TTF1.
- Findings reveal that SSB is highly expressed in LUAD and shows a positive correlation with metabolic activity (SUV), outperforming TTF1 in diagnostic utility, suggesting SSB could be a significant prognostic marker and potential therapeutic target for lung cancer.
Article Abstract
Purpose: The study evaluates the expression and functional significance of the Small RNA Binding Exonuclease Protection Factor La (SSB) gene in lung adenocarcinoma (LUAD). By utilizing F-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) machines, we correlated SSB gene expression with PET/CT parameters, as well as its value in LUAD diagnosis.
Methods: Fifty-five patients with LUAD underwent F-FDG PET/CT imaging prior to pulmonary surgery. Metabolic parameters such as maximum standardized uptake values (SUV) were quantitatively calculated from the F-FDG PET/CT imaging data. The diagnostic value was compared with that of thyroid transcription factor 1 (TTF1, the current standard-of-care). Publicly procurable datasets from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were used to establish SSB gene expression patterns across diverse cancer types and specifically in LUAD, along with its associations with glycolysis and N6-methyladenosine (m6A) modification.
Results: SSB was highly expressed in LUAD compared to adjacent non-cancerous tissues. SSB additionally demonstrated superior diagnostic utility for LUAD compared to TTF1. The correlation between SSB and SUV as well as average standardized uptake values (SUV) was positive (P < 0.001), while TTF1 displayed a negative correlation with metabolic tumor volume (MTV) and total lesion glycolysis (TLG) (P < 0.05).
Conclusion: In LUAD, SSB expression correlated with high metabolic activity (SUV) on F-FDG PET/CT imaging. SSB is not only an important prognostic marker for lung cancer metastases, but may also represent a novel therapeutic target.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11617761 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e38702 | DOI Listing |
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