AI Article Synopsis
- Breast cancer is a complex condition that poses significant public health challenges worldwide, and recent research highlights the role of human microbiota in health and disease, including cancer.
- Findings indicate that the oral-gut microbiome axis plays a role in colorectal cancer through interactions with the immune system and inflammation; however, its influence on breast cancer is less understood.
- This study aims to review the relationship between the oral-gut microbiome and breast cancer, focusing on how it might affect tumor development, treatment efficacy, and patient outcomes, suggesting it could be a key area for future cancer research.
Article Abstract
As a complicated and heterogeneous condition, breast cancer (BC) has posed a tremendous public health challenge across the world. Recent studies have uncovered the crucial effect of human microbiota on various perspectives of health and disease, which include cancer. The oral-gut microbiome axis, particularly, have been implicated in the occurrence and development of colorectal cancer through their intricate interactions with host immune system and modulation of systemic inflammation. However, the research concerning the impact of oral-gut microbiome axis on BC remains scarce. This study focused on comprehensively reviewing and summarizing the latest ideas about the potential bidirectional relation of the gut with oral microbiota in BC, emphasizing their potential impact on tumorigenesis, treatment response, and overall patient outcomes. This review can reveal the prospect of tumor microecology and propose a novel viewpoint that the oral-gut microbiome axis can be a breakthrough point in future BC studies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11617537 | PMC |
| http://dx.doi.org/10.3389/fcimb.2024.1413266 | DOI Listing |
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Article Synopsis
- Breast cancer is a complex condition that poses significant public health challenges worldwide, and recent research highlights the role of human microbiota in health and disease, including cancer.
- Findings indicate that the oral-gut microbiome axis plays a role in colorectal cancer through interactions with the immune system and inflammation; however, its influence on breast cancer is less understood.
- This study aims to review the relationship between the oral-gut microbiome and breast cancer, focusing on how it might affect tumor development, treatment efficacy, and patient outcomes, suggesting it could be a key area for future cancer research.
Periodontal bacteria influence systemic diseases through the gut microbiota.
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Department of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, China.
Many systemic diseases, including Alzheimer disease (AD), diabetes mellitus (DM) and cardiovascular disease, are associated with microbiota dysbiosis. The oral and intestinal microbiota are directly connected anatomically, and communicate with each other through the oral-gut microbiome axis to establish and maintain host microbial homeostasis. In addition to directly, periodontal bacteria may also be indirectly involved in the regulation of systemic health and disease through the disturbed gut.
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