AI Article Synopsis
- Mitochondria are essential organelles in eukaryotic cells, often referred to as the "energy factory," and have a double membrane structure with their own genetic material.
- Alterations in mitochondrial structure and function in tumor cells contribute to aggressive characteristics like rapid growth, invasion, and resistance to treatments, particularly observed in gliomas, the most prevalent type of brain tumor.
- This review discusses how mitochondrial bioenergetics, dynamics, metastasis, and autophagy relate to glioma growth and explores the potential of mitochondria-targeting drugs for glioma treatment.
Article Abstract
Mitochondria, known as the "energy factory" of cells, are essential organelles with a double membrane structure and genetic material found in most eukaryotic cells. They play a crucial role in tumorigenesis and development, with alterations in mitochondrial structure and function in tumor cells leading to characteristics such as rapid proliferation, invasion, and drug resistance. Glioma, the most common brain tumor with a high recurrence rate and limited treatment options, has been linked to changes in mitochondrial structure and function. This review focuses on the bioenergetics, dynamics, metastasis, and autophagy of mitochondria in relation to glioma proliferation, as well as the potential use of mitochondria-targeting drugs in glioma treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621238 | PMC |
| http://dx.doi.org/10.1111/cns.70121 | DOI Listing |
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