Nocturnal blood pressure (BP) shows the highest predictive power for cardiovascular events. However, there is a poor reproducibility of personalized dipping patterns in single individuals. We hypothesize that changes in body position during sleep cause variations in hydrostatic pressure,leading to incorrect BP values and dipping classifications. 26 subjects aged 18-30 years, as well as 25 participants aged 50 years and older underwent ambulatory BP measurements on the left arm, as well as determination of the hydrostatic pressure difference between the cuff and heart level during BP measurement. We observed that the BP measurement cuff was above the heart level (negative hydrostatic pressure) mostly through the night. Laying on the right side revealed the largest hydrostatic pressure difference and maximum incorrect BP measurement, with a mean of -9.61 mmHg during sleep. Correcting for hydrostatic pressure led to reclassification of nocturnal hypertension in 14 subjects (27.5%). Dipping patterns changed in 19 participants (37.3%). In total, 25 subjects (49.0%) changed either their nocturnal hypertension and/or their dipping classification. Our findings underscore the importance of accounting for hydrostatic pressure in ambulatory BP monitoring. Changes in body posture during sleep provide a plausible reason for the variability seen in nocturnal dipping patterns. Further research should focus on incorporating hydrostatic pressure compensation mechanisms in 24-h BP measurement. Limiting the noticeable effect of hydrostatic pressure differences could greatly improve hypertension diagnosis, classification, and treatment monitoring.
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http://dx.doi.org/10.1038/s41440-024-02056-0 | DOI Listing |
Phys Rev Lett
December 2024
Université Grenoble Alpes, CEA, Grenoble INP, IRIG-PHELIQS, F-38000 Grenoble, France.
We experimentally study the evolution of the magnetic moment m and exchange interaction J as a function of hydrostatic pressure in the zero-field helimagnetic phase of the strongly correlated electron system MnSi. The suppression of magnetic order at ≈1.5 GPa is shown to arise from the J collapse and not from a quantum fluctuations induced reduction of m.
View Article and Find Full Text PDFRev Sci Instrum
December 2024
Institute for Solid State Physics, University of Tokyo, 5-1-5 Kashiwanoha, Kashiwa, Chiba 277-8581, Japan.
We have developed a built-in gasket for the Bridgman-type opposed-anvil high-pressure cell, featuring a PTFE (Teflon) capsule of ϕ 2.0 (1.5) × 2.
View Article and Find Full Text PDFACS Nanosci Au
December 2024
Department of Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan.
The dynamic control of chiral (enantiomeric) responses in chiral host-guest complexes through external stimuli is a significant challenge in modern chemistry for developing smart stimuli-responsive materials. Herein, we report the (chir)optical properties and chiral recognition behavior of water-soluble chiral naphthotubes () under the influence of hydrostatic pressure as an external stimulus. The hydrostatic pressure spectral profiles compared to those obtained at normal pressure revealed the dynamic behavior of under hydrostatic pressure, owing to the flexible linker.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
December 2024
Department of Biomedical Engineering, Toyo University, Saitama, Japan.
A previous study reported an increase in carotid-femoral pulse wave velocity (cfPWV) during an upright posture compared to the supine position, partly due to sympathetic activation. However, given that cfPWV is influenced by the transmural pressure (TMP) of the artery, which is elevated in the abdominal aorta in the seated posture due to increased hydrostatic pressure. Thus, it remains unclear whether this increased cfPWV reflects a true rise in arterial stiffness or is simply a result of the elevated TMP.
View Article and Find Full Text PDFPhys Rev E
November 2024
Qingdao Innovation and Development Base, Harbin Engineering University, Qingdao 266000, China.
Dielectric elastomer actuators (DEAs) are an emerging type of soft actuators based on intelligent electroactive polymers. Compared with conventional rigid actuators, DEAs can adapt to extreme hydrostatic pressures without any bulky protective vessels and, therefore, have demonstrated great promises in high-hydrostatic pressure applications such as deep-sea explorations. However, the effects of the enormous hydrostatic compressions on the mechanical and electromechanical coupling properties and electrical breakdown strengths of DEAs remain unclear due to the restrictions in the existing theoretical models and limitations in the experimental techniques developed for DEAs.
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