AI Article Synopsis

  • * A study measured the VN’s cross-sectional area using ultrasound in 96 healthy individuals and 75 PD patients, finding reduced sizes in PD patients overall.
  • * Subgroup analysis indicated that those with the body-first subtype (PD-preRBD) had smaller VN sizes than brain-first subtypes, suggesting that VN ultrasound could help in diagnosing PD.

Article Abstract

The vagus nerve (VN) is the main neural pathway linking the gut and brain in Parkinson's disease (PD). In this study, we utilized high-resolution ultrasound to measure the VN cross-sectional area (CSA) in 96 healthy controls (HCs) and 75 PD patients. The PD group was further categorized into three subgroups: PD-preRBD, PD-postRBD, and PD-nonRBD. PD-preRBD was the body-first subtype, and PD-postRBD and PD-nonRBD were the brain-first subtype. The PD group had a significantly lower VN CSA than HCs. Subgroup analysis revealed that the PD-preRBD group tended to exhibit a smaller VN CSA than both the PD-postRBD and PD-nonRBD groups. The VN CSA, specifically the right VN, was significantly correlated with the body-first subtype and some components of PD-related assessment scales. Overall, these findings provide evidence of VN atrophy in PD, especially in body-first PD, suggesting that VN ultrasound could serve as an adjunctive diagnostic tool.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621687PMC
http://dx.doi.org/10.1038/s41531-024-00844-6DOI Listing

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Article Synopsis
  • * A study measured the VN’s cross-sectional area using ultrasound in 96 healthy individuals and 75 PD patients, finding reduced sizes in PD patients overall.
  • * Subgroup analysis indicated that those with the body-first subtype (PD-preRBD) had smaller VN sizes than brain-first subtypes, suggesting that VN ultrasound could help in diagnosing PD.
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Background: Rapid eye movement (REM) sleep behavior disorder (RBD) could develop preceding or come after motor symptoms during Parkinson's disease (PD). It remains unknown that whether PD with different timing of RBD onset relative to motor symptoms suggests different spatiotemporal sequence of neurodegeneration. This study aimed to explore the sequence of disease progression in crucially involved brain regions in PD with different timing of RBD onset.

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