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CD45RO-Positive Memory T-Cell Density in the Tumoral Core and Invasive Margin Predict Long-Term Survival in Esophageal Squamous Cell Carcinoma. | LitMetric

AI Article Synopsis

  • The study investigates how the presence of CD45RO-positive memory T cells in esophageal squamous cell carcinoma (ESCC) correlates with patient survival rates, particularly since previous research lacked clinical evidence for this cancer type.
  • By analyzing tissue samples from 162 untreated ESCC patients, the research found that higher densities of CD45RO in both the tumor core and invasive margin were linked to improved 5-year overall survival rates.
  • The findings suggest that CD45RO expression density could serve as an independent prognostic indicator for long-term survival in ESCC patients, highlighting its potential importance in cancer prognosis.

Article Abstract

Background: The association between tumor-infiltrating lymphocytes and tumor immunity has long been recognized. Among T-cell types, CD45RO-positive memory T cells (CD45RO) are reported to correlate with survival in several cancer types, but clinical evidence is lacking in esophageal squamous cell carcinoma (ESCC).

Methods: In surgical specimens from 162 preoperatively untreated patients, immunohistochemistry for CD45RO was performed to evaluate the density of CD45RO in the tumor core (CT) and invasive margin (IM) using an auto-count method. Patients were classified into high- versus low-CD45RO groups based on CD45RO density in CT and IM separately and combined. The relationship between CD45RO density and clinicopathological factors, including prognosis, was evaluated.

Results: Average CD45RO density was 133/mm in CT and 372/mm in IM. No significant differences in clinicopathological factors according to high- versus low-CD45RO scores were identified. Using CT scores, the CD45RO-high group had a better 5-year overall survival (OS) rate (77.2% vs. 54.7% CD45RO-low, P = 0.0433), but OS rates did not differ statistically between the two groups by IM scores (75.7% vs. 50.3%, P = 0.0576). Using immunohistochemical scores for CT+IM, the survival difference was significant, with a 5-year OS rate of 73.7% for the CD45RO-high group versus 46.3% for the CD45RO-low group (P = 0.0141). Multivariate analysis identified CD45RO CT+IM density as an independent prognostic variable in OS (hazard ratio 2.27, 95% confidence interval 1.43-3.62, P = 0.0006).

Conclusions: Density of CD45RO expression in the CT and IM might be a predictor of long-term survival in ESCC.

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Source
http://dx.doi.org/10.1245/s10434-024-16530-zDOI Listing

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