Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/d41573-024-00200-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: A significant proportion of individuals maintain healthy cognitive function despite having extensive Alzheimer's disease (AD) pathology, known as cognitive resilience. Understanding the molecular mechanisms that protect these individuals can identify therapeutic targets for AD dementia. This study aims to define molecular and cellular signatures of cognitive resilience, protection and resistance, by integrating genetics, bulk RNA, and single-nucleus RNA sequencing data across multiple brain regions from AD, resilient, and control individuals.
View Article and Find Full Text PDFA mobile interactive cognitive self-assessment scale for screening cognitive impairment due to Alzheimer's disease.
Age Ageing
January 2025
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Background: A mobile cognition scale for community screening in cognitive impairment with rigorous validation is in paucity. We aimed to develop a digital scale that overcame low education for community screening for mild cognitive impairment (MCI) due to Alzheimer's disease (AD) and AD.
Methods: A mobile cognitive self-assessment scale (CogSAS) was designed through the Delphi process, which is feasible for the older population with low education.
Blood phosphorylated Tau181 reliably differentiates amyloid-positive from amyloid-negative subjects in the Alzheimer's disease continuum: A systematic review and meta-analysis.
Alzheimers Dement (Amst)
January 2025
Non Invasive Brain Stimulation Unit Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Rome Italy.
Introduction: Blood-based biomarkers seem promising for the diagnosis of Alzheimer's disease (AD).
Methods: We performed a systematic review and meta-analysis on the potential of blood phosphorylated Tau181 (p-tau181) to differentiate amyloid-positive (A+) and amyloid-negative (A-) subjects. Two meta-analyses were conducted, showing the mean p-tau values in blood and cerebrospinal fluid (CSF) in the A+ and A- group, and the second comparing the mean p-tau concentrations in blood and CSF among A+ versus A- participants, by laboratory assessment method.
Imino and Thioureidic Derivatives as New Tools for Alzheimer's Disease: Preliminary Studies.
Chem Biol Drug Des
January 2025
Department of Health Sciences, University of Basilicata, Potenza, Italy.
Alzheimer's disease is a neurodegenerative chronic disease with a severe social and economic impact in the societies, which still lacks an efficient therapy. Several pathophysiological events (β-amyloid [Aβ] deposits, τ-protein aggregation, loss of cholinergic activity, and oxidative stress) occurs in the progression of the disease. Therefore, the search for efficient multi-targeted agents for the treatment of Alzheimer's disease becomes indispensable.
View Article and Find Full Text PDFOrgan-sparing partial glansectomy: an alternative surgical management for invasive penile carcinoma-case report.
Transl Androl Urol
December 2024
Department of Urology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA.
Background: Penile cancer is a rare malignancy treated via various surgical techniques guided by disease stage and grade with current guidelines suggesting partial or total penectomy for those with pT2 or greater. We report a case of a patient with pT2 squamous cell carcinoma (SCC) of the penis who underwent circumcision with left partial-glansectomy and resection of preputial mass with good oncological control while providing good urinary and sexual function.
Case Description: An 82-year-old male presented to the clinic due to a mass that doubled in size in an 8-month timeframe.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!