Exercise against nonsmall-cell lung carcinoma: novel insights.

Trends Cancer

Physical Exercise and Pediatric Cancer Research Group, Research Institute of the Hospital 12 de Octubre ('imas12'), Madrid, Spain; Department of Sport Sciences, Faculty of Medicine, Health and Sports, Universidad Europea de Madrid, Madrid, Spain.

Published: December 2024

AI Article Synopsis

  • The exact ways in which exercise may help fight cancer are still not fully understood.
  • Recent research by Luo et al. has found that a specific molecule, miR-29a-3p, released from muscle during exercise could play an important role in combating nonsmall-cell lung carcinoma (NSCLC).
  • This molecule may contribute to the body's ability to limit tumor growth and enhance immune responses against cancer through mechanisms involving the extracellular matrix (ECM).

Article Abstract

The mechanisms underlying the potential 'anticancer' effects of exercise remain poorly understood. Luo et al. recently identified an exercise-induced, muscle-derived extracellular vesicle (EV)-associated miR, miR-29a-3p, as a key player in the potential benefits of exercise against nonsmall-cell lung carcinoma (NSCLC), including extracellular matrix (ECM) inhibition and improved antitumoral immune responses.

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Source
http://dx.doi.org/10.1016/j.trecan.2024.11.006DOI Listing

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