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Reconsidering OCD pharmacotherapy: The case for levomilnacipran as a safer alternative to clomipramine.
Pharmacol Biochem Behav
December 2024
Southern Illinois University School of Medicine, Springfield, IL, USA. Electronic address:
The Sapap3 mouse reconsidered as a comorbid model expressing a spectrum of pathological repetitive behaviours.
Transl Psychiatry
January 2023
Team "Neurophysiology of Repetitive Behaviours", Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, AP-HP, Hôpital de la Pitié Salpêtrière, Paris, France.
Symptom comorbidity is present amongst neuropsychiatric disorders with repetitive behaviours, complicating clinical diagnosis and impeding appropriate treatments. This is of particular importance for obsessive-compulsive disorder (OCD) and Tourette syndrome. Here, we meticulously analysed the behaviour of Sapap3 knockout mice, the recent rodent model predominantly used to study compulsive-like behaviours, and found that its behaviour is more complex than originally and persistently described.
View Article and Find Full Text PDFTime to Reconsider Monoamine Oxidase Inhibitors for Obsessive Compulsive Disorder?: A Case Series Using Phenelzine.
J Clin Psychopharmacol
December 2021
From the Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL.
Purpose/background: Despite the availability of a range of efficacious evidence-based treatments for obsessive-compulsive disorder (OCD), not all patients experience sufficient benefit or are able to tolerate them in practice. Monoamine oxidase inhibitors (MAOIs) show efficacy in the treatment of depression and certain anxiety disorders (such as social anxiety disorder).
Methods/procedures: We survey the evidence base from case reports, and clinical trials, regarding use of MAOIs in OCD.
A cross-species assessment of behavioral flexibility in compulsive disorders.
Commun Biol
January 2021
Institut du Cerveau, ICM, Inserm U 1127, CNRS UMR 7225, Sorbonne Université, 47 bd de l'Hôpital, 75013, Paris, France.
Lack of behavioral flexibility has been proposed as one underlying cause of compulsions, defined as repetitive behaviors performed through rigid rituals. However, experimental evidence has proven inconsistent across human and animal models of compulsive-like behavior. In the present study, applying a similarly-designed reversal learning task in two different species, which share a common symptom of compulsivity (human OCD patients and Sapap3 KO mice), we found no consistent link between compulsive behaviors and lack of behavioral flexibility.
View Article and Find Full Text PDFImmune system and obsessive-compulsive disorder.
Psychoneuroendocrinology
July 2018
Universidade Federal do Rio de Janeiro, IDOR, MONASH University, Brazil.
Background: Recently, much attention has been devoted to the possible alterations of the immune system in obsessive-compulsive disorder (OCD). Therefore, the aim of this paper was to review the current literature on the relationships between OCD and immune system.
Methods: A PubMed and Google Scholar search was performed with specific keywords.
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