AI Article Synopsis
- Late-onset Alzheimer's disease (LOAD) is influenced by specific risk alleles that promote cellular senescence, which is associated with aging.
- The study explores how these genetic factors interact with biological aging and highlight differences based on sex.
- These findings provide a better understanding of the mechanisms linking genetic risk and aging processes in the context of Alzheimer's disease.
Article Abstract
Carling et al. report that late-onset Alzheimer's disease (LOAD) risk alleles drive cellular senescence, a hallmark of aging, in a tau- and sex-dependent manner. Mechanistic insights into interactions among genetic risk, biological aging, and sex differences in LOAD are presented.
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| http://dx.doi.org/10.1016/j.neuron.2024.10.025 | DOI Listing |
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