AI Article Synopsis
- Meiotic sex chromosome inactivation (MSCI) is crucial for the proper development of sperm in mammals.
- The study highlights that La Ribonucleoprotein 7 (LARP7) is key for MSCI, promoting germ cell proliferation but displaying different activation stages throughout development.
- In mice lacking LARP7, spermatogenesis halts at the spermatocyte stage, with ongoing transcription of sex chromosome genes, indicating a failure in MSCI and abnormal epigenetic modifications in the XY body.
Article Abstract
Meiotic sex chromosome inactivation (MSCI) is an essential event in meiotic progression in mammalian spermatogenesis. We found that La Ribonucleoprotein 7 (LARP7) is involved in MSCI. LARP7 plays a role in fetal germ cells to promote their proliferation, but is once abolished in postnatal gonocytes and re-expressed in spermatocytes at the onset of meiosis. In spermatocytes, LARP7 localizes to the XY body, a compartmentalized chromatin domain on sex chromosomes. In germline-specific Larp7-deficient mice, spermatogenesis is arrested in spermatocytes, and transcription of the genes on sex chromosomes remained active, which suggests failure of meiotic sex chromosome inactivation (MSCI). Furthermore, the XY body in spermatocytes lacking Larp7 shows accumulation of H4K12ac and elimination of H3K9me2, suggesting defective chromatin silencing by abnormal epigenetic controls. These results indicate a new functional role for LARP7 in MSCI.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620648 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0314329 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!