AI Article Synopsis
- - Scientists identified specific proteins and molecules in the central nervous system (CNS) that can be targeted to create engineered cells for therapy.
- - They developed synthetic Notch receptors to program T cells to release certain treatments only in the brain, effectively clearing brain tumors without affecting cells in other areas.
- - The research also found that T cells delivering interleukin-10, an immune-suppressing cytokine, helped reduce symptoms in a mouse model of neuroinflammation, showing potential for targeted treatment strategies.
Article Abstract
To engineer cells that can specifically target the central nervous system (CNS), we identified extracellular CNS-specific antigens, including components of the CNS extracellular matrix and surface molecules expressed on neurons or glial cells. Synthetic Notch receptors engineered to detect these antigens were used to program T cells to induce the expression of diverse payloads only in the brain. CNS-targeted T cells that induced chimeric antigen receptor expression efficiently cleared primary and secondary brain tumors without harming cross-reactive cells outside of the brain. Conversely, CNS-targeted cells that locally delivered the immunosuppressive cytokine interleukin-10 ameliorated symptoms in a mouse model of neuroinflammation. Tissue-sensing cells represent a strategy for addressing diverse disorders in an anatomically targeted manner.
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| http://dx.doi.org/10.1126/science.adl4237 | DOI Listing |
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