Highly efficient red luminescent organic radicals with less solvent sensitivity are much more attractive due to their wide application in various fields, especially in fluorescence sensing, and bioimaging. In this work, we synthesized a three δ-carboline-capped highly efficient propeller-like organic radical TTM-3δPyID with a D-A structure. The radical showed pure red emission with PLQY of 77.3 % in cyclohexane and kept 35.2 % even in the polar solvent dichloromethane, indicating potential applications in fluorescence sensing. Radical TTM-3δPyID also showed stepwise proton-responsive properties and different emissions at the different states. Furthermore, by taking advantage of the nitrogen site of the radical, we have achieved a fluorescent-quenched radical derivative TTM-3δPyID-AB by introducing of 2-bromoethyl chain through a quaternary ammonium salt reaction. The radical TTM-3δPyID-AB showed turn-on fluorescence in the presence of primary organic amines. Finally, this turn-on fluorescent property is successfully used to distinguish aliphatic amines from aromatic amines.
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http://dx.doi.org/10.1002/asia.202401229 | DOI Listing |
J Nanobiotechnology
December 2024
Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing, 100850, China.
In the post-COVID-19 era, drug-resistant bacterial infections emerge as one of major death causes, where multidrug-resistant Acinetobacter baumannii (MRAB) and drug-resistant Pseudomonas aeruginosa (DRPA) represent primary pathogens. However, the classical antibiotic strategy currently faces the bottleneck of drug resistance. We develop an antimicrobial strategy that applies the selective delivery of CRISPR/Cas9 plasmids to pathogens with biomimetic cationic hybrid vesicles (BCVs), irrelevant to bacterial drug resistance.
View Article and Find Full Text PDFChemosphere
December 2024
Comenius University in Bratislava, Faculty of Natural Sciences, Department of Analytical Chemistry, Ilkovičova 6, SK-842 15 Bratislava, Slovak Republic; University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, CZ-389 25 Vodňany, Czech Republic. Electronic address:
The highly efficient degradation of persistent organic substances by electrochemical advanced oxidation processes (EAOPs), which don't result in the formation of potentially harmful by-products, is crucial for the future of water management. In this study, boron-doped diamond electrodes (BDDE) with three morphologies (planar 2D, microstructured 2D, and macroporous 3D) were employed for the anodic oxidation of diclofenac (DCF) in two working electrolytes (NaCl and NaSO). In total, 11 by-products formed during the electrochemical oxidation of DCF were identified via HPLC-HRMS.
View Article and Find Full Text PDFArch Biochem Biophys
December 2024
Department of Pharmaceutical Sciences, School of Health Sciences and Technology, UPES Dehradun - 248007, Uttarakhand, India. Electronic address:
KRAS (Kirsten rat sarcoma viral oncogene homologue), the most common mutated protein in human cancers, is the leading cause of morbidity and mortality. Before Sotorasib (AMG-510) was approved for non-small cell lung cancer treatment in 2020, the oncogenic KRAS mutations were believed to be non-druggable. High-resolution X-ray crystal structures of GDP-bound KRAS mutants with and without inhibitor resolved.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Nano Drug Delivery Systems (NDDS), Cancer Biology Division, Rajiv Gandhi Centre for Biotechnology, Thycaud P.O, Poojappura, Thiruvananthapuram, Kerala 695014, India. Electronic address:
Severe burns pose significant threats to patient well-being, characterized by pain, inflammation, bacterial infection, and extended recovery periods. While exosome-loaded hydrogels have demonstrated considerable promise in wound healing, current formulations often fall short of achieving optimal therapeutic efficacy for burn wounds due to challenges related to their adaptability to wound shape and limited anti-bacterial capabilities. In this study a novel exosome laden sprayable thermosensitive polysaccharide-based hydrogel (ADA-aPF127@LL18/Exo) comprising alginate dialdehyde (ADA) and aminated Pluronic F127 (aPF127) was fabricated via Schiff base reaction.
View Article and Find Full Text PDFSci Total Environ
December 2024
Department of Civil & Environmental Engineering & Earth Sciences, University of Notre Dame, Notre Dame, IN 46556, United States of America. Electronic address:
Measles is a highly transmissible disease of increasing concern due to waning vaccination contributing to a significant rise in measles cases, with 283 reported cases and 16 outbreaks in the U.S. as of November 7, 2024.
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