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Involvement of CXCL12/CXCR4 in CB2 receptor agonist-attenuated morphine tolerance in Walker 256 tumor-bearing rats with cancer pain.
Eur J Med Res
December 2024
Department of Anesthesiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
While low-dose cannabinoid 2 (CB2) receptor agonists attenuate morphine tolerance in cancer pain models, chemokine ligand 12 (CXCL12)/chemokine receptor 4 (CXCR4) expression induces morphine tolerance. Whether CB2 receptor agonists attenuate morphine tolerance by modulating CXCL12/CXCR4 signaling or whether CXCL12/CXCR4 signaling affects the mu opioid receptor (MOR) in the development of morphine tolerance in cancer pain remains unclear. In this study, we investigated the attenuation of morphine tolerance by a non-analgesic dose of the CB2 receptor agonist AM1241, focusing specifically on the modulation of CXCL12/CXCR4 signaling and its effect on the MOR.
View Article and Find Full Text PDFAnalgesic and Nonanalgesic Prescriptions Among Children and Adolescents With and Without Chronic Pain.
Anesth Analg
December 2024
From the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California.
Non-analgesic effects of opioids: Topical application of Eucerin-based ointment containing opium on the healing process of thermal skin damage in rats.
PLoS One
November 2024
Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences (BUMS), Birjand, Iran.
Article Synopsis
- The study evaluated the effectiveness of Eucerin-based ointments with varying opium concentrations (0.05%, 0.5%, 5%) compared to the standard silver sulfadiazine treatment in treating burn injuries in rats.
- Results indicated that lower concentrations of opium significantly improved wound healing compared to silver sulfadiazine, with the 0.05% opium ointment outperforming it.
- The mixed-group treatment, combining 0.05% opium with silver sulfadiazine, also showed enhanced healing effects, indicating potential benefits of opium in burn treatment.
Pharmacodynamic effects following co-administration of cannabinoids and opioids: a scoping review of human experimental studies.
Pain Med
July 2024
Pediatric Chronic Pain Program, London Health Sciences Centre, London, ON, Canada.
Background: Cannabinoids are increasingly used in the management of chronic pain. Although analgesic potential has been demonstrated, cannabinoids interact with a range of bodily functions that are also influenced by chronic pain medications, including opioids.
Objective: We performed a scoping review of literature on the pharmacodynamic effects following the co-administration of cannabinoids and opioids.
Non-analgesic benefits of combined thoracic epidural analgesia with general anesthesia in on-pump pediatric cardiac surgery: A prospective observational study.
Med J Armed Forces India
April 2023
Senior Advisor (Paediatrics) & Trained in Paediatric Cardiology, Army Hospital (Research & Referral), New Delhi, India.
Background: The use of thoracic epidural analgesia in infants and children could attenuate the stress response and thereby improve the outcomes associated with cardiac surgery.
Methods: This study is a prospective observational study conducted on 118 patients admitted for cardiac surgery. All patients received thoracic epidural analgesia.
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