Background: The application of Artificial Intelligence (AI) in diagnosing retinal diseases represents a significant advancement in ophthalmological research, with the potential to reshape future practices in the field. This study explores the extensive applications and emerging research frontiers of AI in retinal diseases.
Objective: This study aims to uncover the developments and predict future directions of AI research in retinal disease over the past decade.
Methods: This study analyzes AI utilization in retinal disease research through articles, using citation data sourced from the Web of Science (WOS) Core Collection database, covering the period from January 1, 2014, to December 31, 2023. A combination of WOS analyzer, CiteSpace 6.2 R4, and VOSviewer 1.6.19 was used for a bibliometric analysis focusing on citation frequency, collaborations, and keyword trends from an expert perspective.
Results: A total of 2,861 articles across 93 countries or regions were cataloged, with notable growth in article numbers since 2017. China leads with 926 articles, constituting 32% of the total. The United States has the highest h-index at 66, while England has the most significant network centrality at 0.24. Notably, the University of London is the leading institution with 99 articles and shares the highest h-index (25) with University College London. The National University of Singapore stands out for its central role with a score of 0.16. Research primarily spans ophthalmology and computer science, with "network," "transfer learning," and "convolutional neural networks" being prominent burst keywords from 2021 to 2023.
Conclusion: China leads globally in article counts, while the United States has a significant research impact. The University of London and University College London have made significant contributions to the literature. Diabetic retinopathy is the retinal disease with the highest volume of research. AI applications have focused on developing algorithms for diagnosing retinal diseases and investigating abnormal physiological features of the eye. Future research should pivot toward more advanced diagnostic systems for ophthalmic diseases.
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http://dx.doi.org/10.3389/fmed.2024.1489139 | DOI Listing |
PLoS One
January 2025
Department of Radiology, Yantaishan Hospital, Yantai, Shandong, China.
Diabetic retinopathy, a retinal disorder resulting from diabetes mellitus, is a prominent cause of visual degradation and loss among the global population. Therefore, the identification and classification of diabetic retinopathy are of utmost importance in the clinical diagnosis and therapy. Currently, these duties are extensively carried out by manual examination utilizing the human visual system.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
Affiliated Eye Hospital of Nanchang University, Jiangxi Research Institute of Ophthalmology and Visual Science, Jiangxi Provincial Key Laboratory for Ophthalmology, Jiangxi Clinical Research Center for Ophthalmic Disease, Nanchang, China.
Purpose: This study aimed to investigate the role of SIRT4 in retinal protection, specifically its ability to mitigate excitotoxic damage to Müller glial cells through the regulation of mitochondrial dynamics and glutamate transporters (GLASTs).
Methods: A model of retinal excitatory neurotoxicity was established in mice. Proteins related to mitochondrial dynamics, GLAST, and SIRT4 were analyzed on days 0, 1, 3, and 5 following toxic injury.
Invest Ophthalmol Vis Sci
January 2025
School of Graduate, Dalian Medical University, Dalian City, China.
Purpose: To investigate the effect of Ca2+/calmodulin-dependent protein kinase II (CAMKII) δ subtypes (CAMK2D) on sodium iodate (NaIO3)-induced retinal degeneration in mice.
Methods: Bioinformatics analysis and Western blot experiments were used to screen the significantly differentially expressed genes in age-related macular degeneration (AMD) disease. CAMK2D knockdown and overexpression models were constructed by lentivirus (LV) infection of adult retinal pigment epithelial cell line-19 (ARPE-19) cells in vitro.
In Vitro Model
February 2024
iNOVA4Health, NOVA Medical School|Faculdade de Ciências Médicas, NMS|FCM, Universidade Nova de Lisboa, Rua Camara Pestana, 6, Lisbon, Portugal.
Purpose: Diabetic retinopathy (DR) is a complication of diabetes and a primary cause of visual impairment amongst working-age individuals. DR is a degenerative condition in which hyperglycaemia results in morphological and functional changes in certain retinal cells. Existing treatments mainly address the advanced stages of the disease, which involve vascular defects or neovascularization.
View Article and Find Full Text PDFFront Med (Lausanne)
January 2025
Eye Hospital, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Purpose: This study aimed to report the ocular manifestations in individuals with coronavirus disease 2019 (COVID-19) and investigate any correlation between the occurrence of ocular symptoms and systemic symptoms.
Methods: A retrospective electronic survey was conducted among the general public in northern China from December 2022 through February 2023. Inclusion criteria for COVID-19 was confirmed testing positive via a polymerase chain reaction (PCR) test or testing positive for COVID-19 via an antigen kit.
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