AI Article Synopsis
- Hyperthermia enhances cancer treatment by raising cell temperatures to induce damage, often combined with other therapies, making temperature regulation essential.
- The study presents a straightforward method for creating hybrid plasmonic nanodiamonds coated with either an Au shell or Au nanoparticles, which improves both heating and nanoscale temperature measurement.
- These hybrid nanodiamonds effectively generate heat when exposed to light, proving useful in local photothermal therapy for melanoma by successfully eliminating cancer cells while monitoring temperature throughout the process.
Article Abstract
Hyperthermia plays a significant role in cancer treatment by inducing cell damage through temperature elevation, often used alongside other treatment modalities. During hyperthermia therapy, temperature control is crucial. Here, we report on a simple synthesis route of hybrid plasmonic nanodiamonds either completely wrapped with an Au shell () or densely covered with Au NPs ( ). Such integration of nanodiamonds with Au NPs is advantageous both for heating and precise thermometry at nanoscale. After structural and optical investigations, heating abilities of the obtained plasmonic nanodiamonds were thoroughly inspected on glass, in association with living cells, and in tissue slices , revealing their effective heat generation under excitation with light using a single excitation source. The developed hybrid plasmonic nanodiamonds were finally applied for local photothermal therapy of melanoma , demonstrating their efficacy in eradicating cancer cells and monitoring temperature during the process.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11501064 | PMC |
| http://dx.doi.org/10.1515/nanoph-2024-0285 | DOI Listing |
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