Purpose We developed a volumetric quantitative evaluation software called vector volume histogram (VVH) to evaluate respiratory-induced organ motion using deformable image registration (DIR). Methods The B-spline-based DIR algorithm was used to compute the deformation vector field (DVF), which included the DVF (left-right), DVF (anterior-posterior), and DVF (craniocaudal). The VVH software was written as a plug-in using Python, thus allowing anyone to easily modify the code. A shifted target within the moving phantom was used to evaluate the performance of the VVH software. The 2 cm diameter target was systematically shifted by 5, 10, 15, and 20 mm in the CC direction. To evaluate respiration-induced target motion, the VVH method was applied during the inhalation and exhalation phases of 4D CT scans in a patient with lung cancer. Length at 5% volume (L) and length at 50% volume (L) were calculated to evaluate the target motion. Results In the phantom study, the VVH software accurately measured target displacements with L and L values of 5.4 mm and 4.8 mm, 10.4 mm and 9.8 mm, 14.9 mm, and 14.6 mm, and 19.9 mm and 19.6 mm for 5, 10, 15 and 20 mm displacements, respectively. For the lung cancer patient study, the VVH method showed target motion with L and L values of 1.9 mm and 1.8 mm in LR, 1.9 mm and 0.9 mm in AP, 18.8 mm and 15.8 mm in CC, and 18.9 mm and 15.8 mm in 3D vector. The centroid method measured respiratory tumor motion between the inhalation and exhalation phases as 0.5 mm, 0.7 mm, 13.5 mm, and 13.5 mm in the LR, AP, and CC directions and in the 3D vector. Conclusions The VVH software provided a volumetric quantitative assessment of respiratory-induced target motion and may provide strategic decisions for clinical use at the time of treatment planning.
College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, Heilongjiang 150040, PR China. Electronic address:
The widely recognized phytohormone, salicylic acid (SA), serves not only as an exogenous additive for fruits and vegetables but, more crucially, as an in vivo regulator of the entire plant growth process. Consequently, it is essential to achieve both in vitro detection and in vivo imaging analysis of the plant hormone SA. In this study, a biocompatible supramolecular probe was crafted using a "label-free" SA aptamer as the host for an aggregation-induced emission (AIE) organic small molecule.
Background: Adolescent hip dysplasia is a condition that often affects hip mechanics, leading to loss of function, pain, and early onset osteoarthritis. Objective literature investigating functional activities remains sparse within this population. A traditional body weight deep squat has translation to everyday tasks, is a clinical screening tool, and is also a common pre/rehabilitation exercise.
State Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:
Spermatozoa cryopreservation has been widely used for animal genetic conservation. Despite advances in chicken semen cryopreservation, the mechanism of spermatozoa cryodamage remains to be revealed. The cryopreservation process induces motion parameter decreased, structure damaged, proteomic and antioxidant system remodeled in spermatozoa.
Introduction: Improved effectiveness and treatment adherence is needed in smoking cessation (SC) therapies. Another important challenge is to disrupt maladaptive drug-related memories. To achieve these goals, we developed a novel treatment strategy on the basis of motion-assisted memory desensitization and reprocessing (3MDR).
Objective: Lateral ankle sprains (LASs) are prevalent in soccer and can affect long-term performance, injury recurrence and risk for chronic ankle instability. This case-control study examined functional impairments associated with LAS in professional soccer players aged 17-21.
Methods: 40 players were divided into 2 groups: 21 with a history of LAS and 19 healthy matched controls.
