AI Article Synopsis
- Follicle-stimulating hormone (FSH) is produced by the anterior pituitary gland and is crucial for reproductive development by interacting with FSH receptors (FSHR) found in reproductive and non-reproductive tissues.
- FSH levels increase during menopause and remain elevated afterward, which is linked to a higher risk of various non-reproductive diseases like osteoporosis, diabetes, and cardiovascular issues.
- The review focuses on how FSH-FSHR signaling contributes to these diseases and discusses potential therapeutic approaches to target these signaling pathways.
Article Abstract
Follicle-stimulating hormone (FSH), a glycoprotein hormone synthesized and secreted by the anterior pituitary gland, plays a critical role in reproductive development and regulation by binding to FSH receptor (FSHR). Beyond reproductive tissue, FSHRs have been identified in various non-reproductive tissues, indicating broader functions. FSH levels chronically rise during menopause and remain elevated in postmenopausal life. This increase in FSH level has been indicated to be associated with heightened risk of several non-reproductive diseases, including osteoporosis, hypercholesterolemia, type 2 diabetes mellitus, obesity, cardiovascular disease, Alzheimer's disease, and certain cancers. In this review, we will examine the role of FSH-FSHR signaling in the pathogenesis of these non-reproductive diseases and explore therapeutic strategies targeting FSH-FSHR signaling pathways.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615068 | PMC |
| http://dx.doi.org/10.3389/fcell.2024.1506450 | DOI Listing |
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