AI Article Synopsis
- Antiretroviral drug resistance is a growing global issue that threatens efforts to end the HIV epidemic, particularly with rising rates of integrase resistance.
- Heavily treatment-experienced individuals living with HIV face limited treatment options and a higher risk of serious health issues, necessitating better management strategies.
- This review aims to explore effective identification and management of these individuals, focusing on innovative resistance mechanisms and treatment approaches in both resource-rich and resource-limited environments.
Article Abstract
Antiretroviral (ARV) drug resistance poses a threat to ending the HIV epidemic. As the rates of integrase resistance continue to increase globally, the availability of options for HIV treatment becomes limited. Heavily treatment-experienced (HTE) people with HIV (PWH) are limited to two or fewer available fully active ARV classes and are more likely to have an AIDS-defining event. Appropriate identification and management of HTE PWH is crucial to improving patient outcomes and reducing the future spread of drug-resistant HIV. As treatment options become more limited owing to drug resistance, the availability of more potent drugs with a marked increase in virologic suppression is needed in the current ART era. The purpose of this narrative review is to review the identification of HTE PWH, novel mechanisms of resistance, and management of HTE PWH in resource-rich and resource-limited settings using novel ARVs and combination ART.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11618923 | PMC |
| http://dx.doi.org/10.1177/03000605241301883 | DOI Listing |
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