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Cost-effectiveness analysis of pediatric cardiac surgery for common lesions in Rwanda.
Int J Cardiol
December 2024
Department of Cardiothoracic Surgery, Stanford University School of Medicine, 870 Quarry Rd, Palo Alto, CA 94304, USA.
Background: Only 3 % of children in sub-Saharan Africa with congenital heart disease (CHD) have access to life-saving surgery. There is an urgent need to scale up the volume of cardiac procedures. Cost-utility analysis can assess the health economic impacts of performing congenital heart surgery in this region.
View Article and Find Full Text PDFA Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring.
J Vis Exp
November 2024
Department of Surgery, University of Arizona; Department of Biomedical Engineering, University of Arizona;
Hypertrophic scarring (HTS) is an abnormal process of wound healing that results in excessive scar tissue formation. Over the past decade, we have demonstrated that mechanotransduction-the conversion of mechanical stimuli into cellular responses-drives excessive fibrotic scar healing. A mouse model to assess human-like hypertrophic scarring would be an essential tool for examining various therapeutics and their ability to reduce scarring and improve healing.
View Article and Find Full Text PDFAfter decades of growth, a research community's network information system and data repository were transformed to become a national data management office and a major element of data infrastructure for ecology and the environmental sciences. Developing functional data infrastructures is key to the support of ongoing Open Science and Open Data efforts. This example of data infrastructure growth contrasts with the top-down development typical of many digital initiatives.
View Article and Find Full Text PDFThe POD24 challenge: where do we go from here for early progressors?
Hematology Am Soc Hematol Educ Program
December 2024
Division of Hematology and Oncology, Department of Medicine, Wilmot Cancer Institute, University of Rochester, Rochester, NY.
Follicular lymphoma is the most common indolent lymphoma, with a favorable prognosis and survival measured in decades. However, approximately 15% to 20% of patients encounter early disease progression, termed POD24, within 24 months from diagnosis or treatment initiation. Recognizing the correlation between POD24 and a heightened risk of lymphoma-related death has sparked intensive investigations into the clinical and biological determinants of POD24 and the development of innovative treatment strategies targeting this group.
View Article and Find Full Text PDFScoping Review: Association of Inpatient Hospital Design Features With Patients' Clinical Outcomes.
HERD
January 2025
Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
To identify associations between inpatient hospital design features and empirical patient clinical outcomes as well as changes over time. A growing body of literature has emerged evaluating the association of hospital design features with measurable clinical outcomes during inpatient hospital admissions. However, there has been limited effort to evaluate the scope and quality of studies examining individual, inpatient hospital design features on empirical patient clinical outcomes.
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