The highly contagious malaria disease is spread by the female Anopheles mosquito. This disease results in a patient's death or incapacity to move their muscles, if it is not appropriately identified in the early stages. A Rapid Diagnostic Test (RDT) is a frequently used approach to find malaria cells in red blood cells. However, it might not be able to identify infections with small amounts of samples. In the microscopic detection model, blood stains are placed under a microscope for diagnosing malaria. But accurate diagnosis is hard in this method, particularly in developing nations where the disease is most common. The microscopic detection processes are expensive and time-consuming due to the usage of microscopes. The quality of the blood smears and the availability of a qualified specialist, who is skilled in recognizing the disease, impact the accuracy of malaria detection results. The traditional deep learning-based malaria identification models need more processing power. Therefore, a deep learning-based adaptive method is designed to detect malaria cells through the medical image. Hence, the images are gathered from the standard sites and then fed to the segmentation process. Here, the abnormality segmentation is carried out with the help of a developed Trans-MobileUNet + + (T-MUnet + +) network. Trans-MobileUNet + + captures global context, so it is well-suited for segmentation tasks. The segmented image is applied to the adaptive detection phase where the Adaptive and Atrous Convolution-based Recurrent MobilenetV2 (AA-CRMV2) model is designed for the effective recognition of malaria cells. The efficiency of the designed approach is elevated by optimizing the parameters from the AA-CRMV2 network with the help of the Updated Random Parameter-based Fennec Fox Optimization (URP-FFO) algorithm. Several experimental analyses are evaluated in the implemented model over classical techniques to display their effectualness rate.
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http://dx.doi.org/10.1007/s10278-024-01311-7 | DOI Listing |
Trends Parasitol
January 2025
Department of Infectious Diseases, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne 3000, Australia.
In Plasmodium falciparum malaria, infected cells accumulate in blood vessels of organs, including the brain. Recently, Reyes et al. identified monoclonal antibodies that stop infected cells from binding to the endothelial protein C receptor (EPCR) in a model of brain blood vessels.
View Article and Find Full Text PDFContext: Anemia is a medical condition resulting from a reduction in the number of red blood cells below the reference range. It is a major public health problem, particularly among adolescents, as it can have negative effects on cognitive performance, growth and reproduction. This study aims to assess the determinants of anemia among adolescents in schools in the city of Douala.
View Article and Find Full Text PDFNat Med
January 2025
Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Malaria vaccines consisting of metabolically active Plasmodium falciparum (Pf) sporozoites can offer improved protection compared with currently deployed subunit vaccines. In a previous study, we demonstrated the superior protective efficacy of a three-dose regimen of late-arresting genetically attenuated parasites administered by mosquito bite (GA2-MB) compared with early-arresting counterparts (GA1-MB) against a homologous controlled human malaria infection. Encouraged by these results, we explored the potency of a single GA2-MB immunization in a placebo-controlled randomized trial.
View Article and Find Full Text PDFJ Microsc
January 2025
Centre for Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology. Since the discovery of the Plasmodium-infected red blood cells, which cause malaria, microscopy has undergone an impressive development now literally resolving individual molecules.
View Article and Find Full Text PDFNat Commun
January 2025
Centre for translational Medicine and Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Protective immunity to malaria depends on acquisition of parasite-specific antibodies, with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) being one of the most important target antigens. The effector functions of PfEMP1-specific IgG include inhibition of infected erythrocyte (IE) sequestration and opsonization of IEs for cell-mediated destruction. IgG glycosylation modulates antibody functionality, with increased affinity to FcγRIIIa for IgG lacking fucose in the Fc region (Fc-afucosylation).
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