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Epithelial Polarity Loss and Multilayer Formation: Insights Into Tumor Growth and Regulatory Mechanisms.
Bioessays
December 2024
Department of Biochemistry and Molecular Biology, Louisiana Cancer Research Center, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Epithelial tissues serve as critical barriers in metazoan organisms, maintaining structural integrity and facilitating essential physiological functions. Epithelial cell polarity regulates mechanical properties, signaling, and transport, ensuring tissue organization and homeostasis. However, the barrier function is challenged by cell turnover during development and maintenance.
View Article and Find Full Text PDFApproach to death and dying patients and its relation with death anxiety among medical interns: a multicenter cross-sectional study.
BMC Psychol
December 2024
Faculty of Medicine, Albalqaa Applied University, Al-Salt, Jordan.
Background: Dealing with death and dying patients is one of the most challenging aspects of medical practice. The purpose of this study was to assess the attitude of medical interns toward death and dying patients as well as their level of death anxiety.
Methods: This cross-sectional study was conducted on medical interns across three countries-Egypt, Jordan, and Palestine-using an online survey created with Google Forms.
Implantable cardioverter defibrillator deactivation and end-of-life: British Heart Rhythm Society practical consensus guideline.
BMJ Support Palliat Care
December 2024
Wolfson Palliative Care Research Centre, University of Hull, Hull, UK.
Implantable cardioverter defibrillators (ICDs) are implanted in increasing numbers of patients with the aim of treating ventricular arrhythmias in high-risk patients and reducing their risk of dying. Individuals are also living longer with these devices. As a result, a greater number of patients with an ICD will deteriorate either with worsening cardiac failure, another non-cardiac condition or general frailty and will have a limited prognosis.
View Article and Find Full Text PDFCharacteristics of patients who die in an acute palliative care unit.
Support Care Cancer
December 2024
Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90127, Palermo, Italy.
Article Synopsis
- The study assessed characteristics and death risk factors for advanced cancer patients in an acute palliative care unit (APCU).
- Fifty-four out of 450 patients (12%) died in the APCU, with significant differences noted in aspects like cognitive decline, referral source, cachexia, and symptom burden between those who died and those who were discharged alive.
- Key factors linked to dying in APCU included being referred from home palliative care, experiencing high symptom burdens, and being off cancer treatment, indicating the need for improved end-of-life care strategies for these patients.
Reframing assisted dying through the civil law: possibilities and challenges for the UK.
BMJ Support Palliat Care
December 2024
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Background: Current proposals for assisted dying in the UK are based on embedding it within a medical, healthcare model. This model is revealing challenges in safeguarding, monitoring and the impact on healthcare.
Objective: To explore if a different model is a safer, pragmatic and realistic alternative.
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