Cold piezoelectric plasma (CPP) is a novel approach in cancer therapy, enabling the development of portable treatment devices capable of triggering cancer cell death. While its effectiveness remains underexplored, this research focuses on its application against cholangiocarcinoma (CCA), an aggressive cancer of the biliary tract. A CPP device is utilized to generate either a corona discharge (Pz-CD) or a dielectric barrier discharge (Pz-DBD) for in vitro experiments. Notably, Pz-CD can deliver more power than Pz-DBD, although both sources produce significant levels of reactive species in plasma and liquid phases. This work shows that CPP causes a gradient increase in medium temperature from the center towards the edges of the culture well, especially for longer treatment times. Although Pz-CD heats more significantly, it cools quickly after plasma extinction. When applied to human CCA cells, CPP shows immediate and long-term effects, more localized for Pz-CD, while more uniform for Pz-DBD. Immediate effects result also in actin cytoskeleton remodeling without alteration of the cell membrane permeability. Long-term effects of CPP, although the antioxidant system is engaged, include activation of the DNA damage response pathway leading to cell death. In conclusion, CPP should be recognized as a promising antitumor therapy.
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http://dx.doi.org/10.1038/s41598-024-81664-9 | DOI Listing |
Sci Rep
December 2024
Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, F-75012, Paris, France.
Cryogenic trapped-ion systems (CTISs) have emerged as indispensable platforms for the advancement of quantum computation and precision measurement techniques. However, the sensitivity of these systems to vibrational noise, especially during the compression and expansion cycles of the cold head in a Gifford-McMahon cycle refrigerator (GMCR), poses a significant challenge. To mitigate this, we have crafted an innovative methodology for characterizing low-frequency residual vibrational noise in closed-cycle cryogenic trapped-ion systems.
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November 2024
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Institute of Functional Materials, College of Materials Science and Engineering, Donghua University, Shanghai, China.
The modulation of the electrostatic potential barrier at grain boundaries determines the performance of many ceramic-based electronics such as varistors. However, conventional protocols relying on complex doping and annealing processes inevitably increase the inhomogeneity of microstructure, which may jeopardize the performance stability and mechanical reliability in service. Instead of doping, herein we demonstrate an effective strategy to modulate the potential barrier in ZnO-based low-voltage varistors by exploiting internal stress-induced piezoelectric polarization.
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November 2024
Faculty of Engineering and Environment, Northumbria University, Newcastle upon Tyne NE1 8ST, U.K.
In this study, we introduced an integrated approach using piezoelectric thin film-based surface acoustic wave (SAW) and wireless power transfer (WPT) technologies, designed for both passive monitoring and active defogging/icing functions. We systematically investigated the resonant frequency shifts of ZnO/glass SAW devices, establishing their correlations with variations in humidity and temperature under cold conditions. Acoustic waves generated through the ZnO/glass SAW device were used for defogging and deicing functions with effects of RF powers and acousto-heating thoroughly evaluated.
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March 2024
School of Applied Sciences, College for Health, Science and Society, University of the West of England, Coldharbour Ln, Bristol BS16 1QY, UK.
Cold atmospheric plasma (CAP) is a novel non-thermal technology with significant potential for use in meat processing to prolong shelf life. The objective of the study was to evaluate the efficiency of CAP treatment on the natural microbiota and quality traits of pork stored for 8 days at 4 °C. CAP treatment was applied by employing piezoelectric direct discharge technology to treat pork samples for 0, 3, 6, and 9 min.
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