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Lighting Up Dual-Aptamer-Based DNA Logic-Gated Series Lamp Probes with Specific Membrane Proteins for Sensitive and Accurate Cancer Cell Identification.
Anal Chem
January 2025
Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Cixi Biomedical Research Institute, School of Laboratory Medicine and Life sciences, Wenzhou Medical University, Wenzhou 325035, China.
Accurate identification of cancer cells under complex physiological environments holds great promise for noninvasive diagnosis and personalized medicine. Herein, we developed dual-aptamer-based DNA logic-gated series lamp probes (Apt-SLP) by coupling a DNA cell-classifier (DCC) with a self-powered signal-amplifier (SSA), enabling rapid and sensitive identification of cancer cells in a blood sample. DCC is endowed with two extended-aptamer based modules for recognizing the two cascade cell membrane receptors and serves as a DNA logic gate to pinpoint a particular and narrow subpopulation of cells from a larger population of similar cells.
View Article and Find Full Text PDFBackground: The Multicomponent Intervention to Improve Acute Myocardial Infarction Care (MIMIC) was developed to increase uptake of evidence-based care for acute myocardial infarction in Tanzania. MIMIC consists of five components: triage cards, pocket cards, an online training module, patient educational pamphlets, and clinical champions. Our aim was to determine the acceptability and feasibility of this intervention among emergency department (ED) providers in Tanzania.
View Article and Find Full Text PDFMulticomponent Synergistic Doping Enables High-efficiency n-Type PbTe Thermoelectric Devices.
Small
December 2024
College of Materials Science and Engineering, Guangdong Provincial Key Laboratory of New Energy Materials Service Safety, Guangdong Research Center for Interfacial Engineering of Functional Materials, Institute of Deep Underground Sciences and Green Energy, Shenzhen University, Shenzhen, 518060, P. R. China.
The development of high-performance n-type PbTe thermoelectric (TE) modules is urgently needed to match those p-type IV-VI tellurides (i.e., PbTe, GeTe, SnTe) with high figure of merit (ZT) to obtain multi-pair TE devices for practical applications.
View Article and Find Full Text PDFTopological Transformation and Dimensional Reduction in Multicomponent Metal-Organic Frameworks for Gas Separations.
Adv Mater
December 2024
School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
Multicomponent MOFs have offered a wide range of opportunities to harness new properties. However, the synthesis of multicomponent MOFs remains challenging. This work demonstrates the synthesis of a family of multicomponent MOFs by topological transformation from well-established multicomponent partitioned acs (pacs) structures.
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