Rongalite-mediated one-pot aminomethylation of heteroarenes using secondary amines/anilines has been developed. This transition-metal-free and mild reaction offers an efficient way to synthesize aminomethylated heteroaromatic compounds with high yields and broad functional group tolerance. Here, Rongalite plays a key role in generating the C1 unit source , which triggers the aminomethylation process. This approach provides a library of aminomethylated imidazo[1,2-]pyridines and imidazo[2,1-]thiazoles.
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One-Pot Aminomethylation of Heteroarenes by Rongalite as C1 Source.
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