AI Article Synopsis
- Therapeutic drug monitoring (TDM) for biologic therapies in inflammatory bowel disease (IBD) focuses on optimizing medication doses but faces challenges like identifying ideal drug levels and dealing with variability in drug response.
- Recent advancements, including population pharmacokinetic/pharmacodynamic (PK/PD) modeling and model-informed precision dosing (MIPD) tools, as well as point-of-care testing and new software, present promising solutions to these challenges.
- Implementing these innovations could lead to personalized dosing strategies, moving away from the current one-size-fits-all approach that doesn't meet the diverse needs of IBD patients.
Article Abstract
Therapeutic drug monitoring (TDM) for biologic therapies in inflammatory bowel disease (IBD) primarily aims to optimize dosing. However, several unmet needs remain. These include the identification of optimal drug concentrations, accounting for variability in pharmacokinetics (PK) and pharmacodynamics (PD), and the frequent delays between sampling and clinical decision-making. Recent technical advances, such as population PK/PD modeling and model-informed precision dosing (MIPD) tools developed from such models, as well as point-of-care (POC) and self-sampling assays and novel software programs, offer potential solutions. Successful implementation of these innovations may help to establish MIPD for patients with IBD. This would enable personalized dosing, advancing a one-size-fits-all approach to TDM that currently is inadequate to fulfill the needs for every patient with IBD.
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| http://dx.doi.org/10.1016/j.tips.2024.11.003 | DOI Listing |
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- Therapeutic drug monitoring (TDM) for biologic therapies in inflammatory bowel disease (IBD) focuses on optimizing medication doses but faces challenges like identifying ideal drug levels and dealing with variability in drug response.
- Recent advancements, including population pharmacokinetic/pharmacodynamic (PK/PD) modeling and model-informed precision dosing (MIPD) tools, as well as point-of-care testing and new software, present promising solutions to these challenges.
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