The objective of this study was to optimize the utilization of deposited fat in Sunit sheep, with a focus on dietary nutrition. This study also elucidated variations in lipid metabolism among subcutaneous fat (SF), perirenal fat (PF), and tail fat (TF) in sheep of different ages using non-targeted lipidomic techniques. In total, 173 different lipids were identified, of which triacylglycerol (TG) and phosphatidylcholine (PC) were prominent. The relative intensity of TG was highest at 6 months of age in three adipose depots. Glycerophospholipids (PLs) were expressed at peak levels in TF and SF at 18 months of age. Pathway analysis revealed that biosynthesis of unsaturated fatty acids, linoleic acid metabolism, glycerophospholipid metabolism, and fatty acid biosynthesis were the main pathways involved in the metabolism of adipose depots. These findings provide a comprehensive reference for the metabolic characteristics and pathways of adipose tissue in sheep and the utilization of its by-products.
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http://dx.doi.org/10.1016/j.foodchem.2024.142243 | DOI Listing |
Curr Vasc Pharmacol
January 2025
1st Department of Cardiology, 'Hippokration' General Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Introduction: Sodium-glucose cotransporter 2 (SGLT2) inhibitors have emerged as a groundbreaking class of antidiabetic medications renowned for their glucose-lowering effects and cardiovascular benefits. Recent studies have suggested that SGLT2 inhibitors may extend their influence beyond glycemic control to impact adipose tissue physiology, particularly within the epicardial adipose depot. Epicardial adipose tissue (EAT), an actively secretory organ surrounding the heart, has been implicated in the modulation of cardiovascular risk.
View Article and Find Full Text PDFCurr Obes Rep
January 2025
Maine Medical Center Research Institute, Maine Medical Center, 81 Research Drive, Scarborough, ME, 04074, USA.
Purpose Of Review: Bone marrow adipose tissue is a distinctive fat depot located within the skeleton, with the potential to influence both local and systemic metabolic processes. Although significant strides have been made in understanding bone marrow adipose tissue over the past decade, many questions remain regarding their precise lineage and functional roles.
Recent Findings: Recent studies have highlighted bone marrow adipose tissue's involvement in continuous cross-talk with other organs and systems, exerting both endocrine and paracrine functions that play a crucial role in metabolic homeostasis, skeletal remodeling, hematopoiesis, and the progression of bone metastases.
Elife
January 2025
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, United States.
Single-nucleus RNA sequencing (snRNA-seq), an alternative to single-cell RNA sequencing (scRNA-seq), encounters technical challenges in obtaining high-quality nuclei and RNA, persistently hindering its applications. Here, we present a robust technique for isolating nuclei across various tissue types, remarkably enhancing snRNA-seq data quality. Employing this approach, we comprehensively characterize the depot-dependent cellular dynamics of various cell types underlying mouse adipose tissue remodeling during obesity.
View Article and Find Full Text PDFDiabetes Obes Metab
January 2025
Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, People's Republic of China.
Background: The body weight following bariatric surgery is a primary concern for both healthcare professionals and surgical candidates. However, it remains unclear whether variations in preoperative fat distribution influence weight loss outcomes.
Objective: The aim of this study was to evaluate the effect of abdominal fat distribution on postoperative weight loss and body mass index (BMI) reduction, and to clarify the role of different fat depots in weight loss outcomes.
Int J Mol Sci
December 2024
Laboratorio Universitario de Análisis Clínicos e Investigación, Universidad de Sonora (LUACI) Departamento de Ciencias Químico-Biológicas y Agropecuarias, Campus Navojoa. Lázaro Cárdenas del Río #100, CP 85880 Navojoa, Sonora, Mexico.
Sucralose, a commonly nonnutritive sweetener used in daily products of habitual diet, is related to impairing the gut microbiome by disrupting inflammatory response, promoting weight gain by increasing adipose tissue and promoting chronic inflammatory processes. Considering the impact of sucralose in the development of metabolic diseases, in this work, we focused on the impact of sucralose on the adipocyte differentiation process to determine if sucralose can promote adipogenesis and increase adipose tissue depots in PCS 210 010 human preadipocytes cell line. Sucralose at 25 (S25) and 100 ng/µL (S100) concentrations were tested against control with no edulcorant (NS) during the adipocyte differentiation process at 48 h and 96 h.
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