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Filarial Epididymitis: A Diagnostic Challenge in Pediatric Acute Scrotum.
Cureus
November 2024
General Surgery, Mount Zion Medical College Hospital, Adoor, IND.
Genital lymphatic filariasis (LF) is a condition that can present both acutely and chronically, complicating its diagnosis due to nonspecific symptoms. This case report describes an 11-year-old boy who presented with symptoms of acute scrotum. Initial Doppler ultrasound suggested acute epididymo-orchitis; however, despite conservative management, the symptoms persisted, prompting surgical exploration.
View Article and Find Full Text PDFDifferences in Cytokine Expression at Baseline and in Response to Mineral Stimulation by Peripheral Blood Mononuclear Cells from Podoconiosis Cases and Healthy Control Individuals.
Trop Med Infect Dis
October 2024
Armauer Hansen Research Institute, Addis Ababa P.O. Box 1005, Ethiopia.
Article Synopsis
- Podoconiosis is a non-infectious tropical lymphoedema affecting around 4 million people, linked to HLA class II and triggered by unknown factors in volcanic red clay soils.
- The study measured immune responses in podoconiosis patients by analyzing cytokine levels and gene expressions after exposure to specific minerals, finding that patients had higher baseline cytokine levels but lower responses to mineral stimulation.
- The findings indicate ongoing immune activation in podoconiosis patients, highlighting the need for further research to understand immune dysfunction and potentially develop early detection methods for this preventable disease.
Article Synopsis
- Podoconiosis is a little-known form of lymphoedema with uncertain global distribution, and recent studies aimed to assess its presence in Guatemala and Idukki District, India.
- In Guatemala, researchers visited municipalities with suspected cases and ruled out podoconiosis in all examined cases, while in Idukki District, a large survey identified other causes of lower limb swelling, confirming no cases of podoconiosis.
- The findings suggest that podoconiosis is not currently endemic in either Guatemala or Idukki District, indicating potential success in addressing this health issue.
Designing of a chimeric multiepitope vaccine against bancroftian lymphatic filariasis through immunoinformatics approaches.
PLoS One
September 2024
Department of Cellular and Molecular Biology, Faculty of Biotechnology and Genetic Engineering, Chattogram Veterinary and Animal Sciences University (CVASU), Chattogram, Bangladesh.
Article Synopsis
- The study focuses on designing a vaccine for lymphatic filariasis caused by Wuchereria bancrofti using immunoinformatics approaches to target specific proteins.
- Two vaccine candidates, V1 and V2, were developed and analyzed for their structural stability and binding affinity to immune receptors, with V1 showing better results.
- Strong immunological responses were observed in a three-dose vaccination analysis, suggesting V1's potential efficacy, but further testing is needed to fully validate its effectiveness.
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