Herein, we describe a reliable and efficient approach for the first chemical synthesis of biologically significant and complex 3--(-3-hydroxydecanoyl) modified uridine diphosphate -acetylglucosamine that is the native substrate of LpxC involved in the biosynthesis of the cell wall of . The synthetic protocol provides a successful example for the reliable preparation of modified nucleoside diphosphate sugar, which features judiciously selected protecting groups, the formation of pyrophosphate linkage with 5'-phosphate nucleoside as nucleophile, and the straightforward purification process.
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| http://dx.doi.org/10.1021/acs.orglett.4c04042 | DOI Listing |
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667732 | PMC |
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