AI Article Synopsis
- * The study investigated the impact of fecal microbiota transplantation (FMT) on rats poisoned with MeHg over a 14-day treatment period, analyzing neurological behaviors, weight changes, and levels of MeHg and dopamine.
- * Results showed that FMT significantly improved weight gain, reduced neurological problems, increased mercury excretion, restored gut microbiota, and boosted beneficial metabolites, suggesting potential applications for treating neurological conditions like Parkinson's Disease.
Article Abstract
Methylmercury (MeHg) can cause devastating neurotoxicity in animals and human beings. Gut microbiota dysbiosis has been found in MeHg-poisoned animals. Fecal microbiota transplantation (FMT) has been shown to improve clinical outcomes in a variety of diseases such as epilepsy, amyotrophic lateral sclerosis (ALS) and autism. The aim of this study was to investigate the effects of FMT on MeHg-poisoned rats. FMT treatment was applied to MeHg-poisoned rats for 14 days. The neurobehavior, weight changes, dopamine (DA), the total Hg and MeHg level were evaluated. Besides, the gut microbiota and metabolites change in feces were also checked. It was found that FMT helped weight gain, alleviated the neurological disorders, enhanced fecal mercury excretion and MeHg demethylation, reconstructed gut microbiome and promoted the production of gut-brain axis related-metabolites in MeHg-poisoned rats. This study elaborates on the therapeutic efficacy of FMT in treating of MeHg-poisoned rats, which sheds lights on the treatment of neurological diseases like Minamata Disease and even Parkinson's Disease.
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| http://dx.doi.org/10.1016/j.scitotenv.2024.177850 | DOI Listing |
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