AI Article Synopsis
- Arteriovenous grafts, used in hemodialysis, often face serious issues like thrombosis and infections that hinder their effectiveness.
- Researchers created a surface-modified nanohybrid hydrogel by combining clay nanoparticles coated with zwitterionic sulfobetaine methacrylate onto a sodium alginate/polyvinyl alcohol base.
- This new hydrogel demonstrated improved mechanical strength, biocompatibility, and antifouling properties, making it a promising option for use in blood-contacting implants.
Article Abstract
Arteriovenous grafts are routinely designed to provide a deliberate connection between an artery and vein in patients during hemodialysis. The commonly used grafts present significant drawbacks such as thrombosis, bacterial infection, and biofouling which prevents their functionality. To endow hydrogels with improved anti-thrombosis, stable antifouling, and strong mechanical strength, a surface-modified nanoparticle-reinforced nanohybrid hydrogel is developed. In brief, zwitterionic sulfobetaine methacrylate (SBMA) is coated on bentonite clay (BC) nanoparticles via a simple method. BC-SBMA nanoparticles were then loaded onto sodium alginate /polyvinyl alcohol hydrogel composite. Calcium chloride (Ca) crosslinking is employed to form stable network and optimize polyvinyl alcohol/sodium alginate (PS) hydrogel composite. BC-SBMA particles were dispersed into PS hydrogel and crosslinked to form nanohybrid hydrogel (PS@BC-SBMA). The nanohybrid hydrogel was characterized for its morphological, mechanical, physicochemical, antibacterial, biocompatibility, antifouling, ex-vivo anti-thrombogenic, and in-vivo anti-inflammatory properties. The results revealed that the presence ofBC-SBMA particles boosted the mechanical strength and facilitated biocompatibility. The presence of zwitterionic polymers provided excellent antifouling properties toward blood platelets, unnecessary proteins, and bacterial strains. Hence, the cooperative effects of the nanohybrid hydrogel such as biocompatibility, antifouling, and mechanical properties lead to a desirable candidate for blood-contacting implants.
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| http://dx.doi.org/10.1016/j.colsurfb.2024.114420 | DOI Listing |
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Article Synopsis
- Arteriovenous grafts, used in hemodialysis, often face serious issues like thrombosis and infections that hinder their effectiveness.
- Researchers created a surface-modified nanohybrid hydrogel by combining clay nanoparticles coated with zwitterionic sulfobetaine methacrylate onto a sodium alginate/polyvinyl alcohol base.
- This new hydrogel demonstrated improved mechanical strength, biocompatibility, and antifouling properties, making it a promising option for use in blood-contacting implants.
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