In fighting infectious diseases posing a global health threat, ranging from influenza to Zika, nonpharmaceutical interventions (NPI), such as social distancing and face covering, remain mitigation measures public health can resort to. However, the success of NPI lies in sufficiently high levels of collective compliance, otherwise giving rise to recurrent infections that are not only driven by pathogen evolution but also changing vigilance in the population. Here, we show that compliance with each NPI measure can be highly dynamic and context-dependent during an ongoing epidemic, where individuals may prefer one to another or even do nothing, leading to intricate temporal switching behavior of NPI adoptions. By characterizing dynamic regimes through the perceived costs of NPI measures and their effectiveness in particular regarding face covering and social distancing, our work offers insights into overcoming barriers in NPI adoptions.
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http://dx.doi.org/10.1073/pnas.2407308121 | DOI Listing |
Lancet HIV
January 2025
Division of Infectious Diseases, Hennepin Healthcare, Minneapolis, MN, USA; University of Minnesota, Minneapolis, MN, USA. Electronic address:
Despite advancements in existing antiretroviral-based prevention strategies, including daily oral, locally acting, and injectable options, there is a pressing need for more inclusive and flexible event-driven pre-exposure prophylaxis (PrEP) strategies for all. Event-driven or intermittent dosing of PrEP in populations beyond cisgender men who have sex with men would offer a promising alternative by fitting prevention into the diverse lifestyles of affected populations and thereby advancing health equity. Evidence from PrEP clinical trials, pharmacokinetic studies, modelling studies, and real-world observational research suggests that event-driven PrEP could be a flexible and inclusive option, yet optimal dosing has not been established across sex and gender spectrums.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Background: Experience-dependent cognitive plasticity can be induced by cognitive training well into the later decades of life. Although some prerequisites (education, intelligence) and constraints (age, genetic predisposition) on the extent of cognitive plasticity have been discussed, the impact of molecular age-related changes in the form of fibrillar amyloid pathology on plasticity remains to be investigated. Expanding our knowledge of potential contributors to the observed heterogeneity in intervention benefits may allow us to improve non-pharmaceutical interventions METHOD: Seventy-six healthy older adults (mean age = 68.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Instituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain; Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada., Granada, Granada, Spain; CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain.
In the quest to combat Alzheimer's disease (AD), physical exercise has emerged as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. The limited understanding of the mechanisms by which exercise impacts cognition in late adulthood hinders the widespread use of exercise as a therapeutic or preventive approach for AD. This underscores the urgent need for research aimed at unraveling the mechanisms by which exercise improves cognition.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Laboratory of Clinical Investigation, National Institute on Aging, Intramural Research Program, Baltimore, MD, USA.
Background: Alterations in grey matter (GM) are known to contribute to cognitive decline in aging and dementia. Recent evidence suggests that individuals with higher cardiorespiratory fitness (CRF) may have a lower risk of GM atrophy and subsequent cognitive decline. However, the role of cortical myelination in cognitive decline and its association with CRF remains elusive.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
1 Aga Khan University, Brain and Mind Institute, 3rd Parklands Avenue, Nairobi, Kenya, Nairobi, Nairobi, Kenya.
Background: In 2023, the World Health Organization (WHO) presented the Mental Health Gap Action Programmes to avert Dementia. In this publication, the WHO presented a high certainty that physical activity interventions prevent Dementia. The organization presented low levels of certainty that psychosocial interventions, non-pharmaceutical interventions, depression, and anxiety treatments are effective for Dementia prevention in low-income and middle-income countries (LMICs).
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