Mutations in the gene that result in a lack of expression of histo-blood group antigens on secreted glycoproteins may shape the vaginal microbiota with consequences for birth outcome. To test this, we analysed the relationship between secretor status, vaginal microbiota and gestational length in an ethnically diverse cohort of 302 pregnant women, including 82 who delivered preterm. and were found to have distinct co-occurrence patterns with other microbial taxa in non-secretors. Moreover, non-secretors with spp. depleted high diversity vaginal microbiota in early pregnancy had significantly shorter gestational length than spp. dominated non-secretors (mean of 241.54 days (sd=47.14) versus 266.21 (23.61); -value=0.0251). Similar gestational length differences were observed between non-secretors with high vaginal diversity and secretors with spp. dominance (mean of 262.52 days (SD=27.73); -=0.0439) or depletion (mean of 266.05 days (SD=20.81); -=0.0312). Our data highlight secretor status and blood-group antigen expression as being important mediators of vaginal microbiota-host interactions in the context of preterm birth risk.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11616779 | PMC |
http://dx.doi.org/10.1099/mgen.0.001323 | DOI Listing |
Cureus
November 2024
Forensic Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Heliyon
October 2024
Nutrition Research Institute, Junlebao Dairy Groups Co. Ltd, No.36 Shitong Road, Luquan, Shijiazhuang, Hebei, China.
Human milk Oligosaccharides (HMOs) are a major component in human milk and recognized to play an important role in modulating gut microbiota, intestinal cell response, and the development of the brain and immune system. While HMOs levels from Chinese mothers across different regions of China have been reported, data from Hebei are lacking. Twelve HMOs were measured from a cross-section of Hebei Han mothers over a 15-month lactation period.
View Article and Find Full Text PDFMicrob Genom
December 2024
March of Dimes European Prematurity Research Centre, Imperial College London, London, UK.
J Eur Acad Dermatol Venereol
November 2024
Center of Expertise on Autoimmune Bullous Diseases, Second Department of Dermatology, School of Medicine, Papageorgiou Hospital, Aristotle University, Thessaloniki, Greece.
J Nutr
November 2024
Department of Nursing, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China.
Background: Human milk oligosaccharides (HMOs) and other milk-derived metabolites are crucial for infant health, influencing gut microbiota and overall development.
Objective: This study aimed to uncover insights into the variations of HMOs and non-HMO metabolites based on secretor (Se) status, lactation time, mode of delivery, and infant sex.
Methods: An exploratory cross-sectional study was designed to compare the concentrations of HMOs and non-HMOs metabolites in milk samples from 129 lactating Chinese women within 1 y postpartum.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!