Reported here is a set of three-component reactions of enaminones with diaryl phosphine oxides and water for the synthesis of ketomethylene-functionalized -phosphoryl alcohols enaminone hydrodifunctionalization, enabling the cascade construction of new C-P, C-O and C-H bonds. The method displays notable advantages including mild metal-free conditions, a broad application scope and being free of the need to carry out chromatographic purification.
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Metal-free hydrodifunctionalization of enaminones for the synthesis of ketomethylene-functionalized phosphoryl alcohols.
Org Biomol Chem
January 2025
Jiangxi Province Key Laboratory of Natural and Biomimetic Drugs Research, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, China.
Reported here is a set of three-component reactions of enaminones with diaryl phosphine oxides and water for the synthesis of ketomethylene-functionalized -phosphoryl alcohols enaminone hydrodifunctionalization, enabling the cascade construction of new C-P, C-O and C-H bonds. The method displays notable advantages including mild metal-free conditions, a broad application scope and being free of the need to carry out chromatographic purification.
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