AI Article Synopsis
- * Utilizing the Global Burden of Disease approach, researchers observed that in 2021, there were 118,878 new cases of NPC worldwide, with significant male predominance and higher impacts in East and Southeast Asia.
- * Despite a decrease in age-standardized incidence rates, the absolute number of NPC cases is rising due to better diagnostics and an aging population, indicating a need for improved prevention and tailored health policies.
Article Abstract
Background: This study analyzes nasopharyngeal carcinoma (NPC) from 1990 to 2021 across 204 countries, focusing on prevalence, incidence, mortality, and disability-adjusted life years (DALYs). It examines gender disparities, regional variations, age dynamics, and temporal trends to provide insights for health policy and resource allocation.
Methods: We used the Global Burden of Disease (GBD) approach to assess NPC's health burden, including incidence, prevalence, mortality, and DALYs. Trends from 1990 to 2021 were illustrated using estimated annual percent change (EAPC). Subgroup analysis revealed variations by gender, age, Socio-Demographic Index (SDI), GBD classification, and country. Age-period-cohort (APC) and Bayesian age-period-cohort (BAPC) models predicted future trends.
Results: In 2021, there were 118,878 new NPC cases globally (1.38 per 100,000), with a prevalence of 525,219 cases (6.14 per 100,000), 75,359 deaths (0.87 per 100,000), and 249,019 DALYs (28.91 per 100,000). Males had higher rates across all metrics. Incidence peaked at ages 50-54, mortality at 70-74, and DALYs at 50-54. High SDI regions, especially East and Southeast Asia, showed higher burdens. Despite decreasing age-standardized incidence rates, absolute cases are rising, necessitating improved prevention and treatment strategies.
Conclusions: NPC prevalence has increased due to better diagnosis and aging populations, despite decreasing age-adjusted incidence rates. Lower mortality rates indicate improved treatment. Males, especially in East and Southeast Asia, bear a higher NPC burden. These findings highlight the need for targeted interventions and tailored public health policies in high-risk regions.
Level Of Evidence: III Laryngoscope, 2024.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/lary.31939 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Global, regional, and national burden of male breast cancer in 204 countries and territories: a systematic analysis from the global burden of disease study, 1990-2021.
EClinicalMedicine
February 2025
Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Background: Male breast cancer (MBC) is a rare malignancy that has been under-investigated, with limited global epidemiological research dedicated to it. A comprehensive estimate of the global, regional, and national burden of MBC is valuable for policy planning. This study aims to evaluate the burden of MBC across 204 countries and territories.
View Article and Find Full Text PDFBurden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021.
World J Psychiatry
January 2025
Department of Health Management Centre, Zhongshan Hospital, Fudan University, Shanghai 200030, China.
Background: The burden of mental disorders (MD) in the Western Pacific Region (WPR) remains a critical public health concern, with substantial variations across demographics and countries.
Aim: To analyze the burden of MD in the WPR from 1990 to 2021, along with associated risk factors, to reveal changing trends and emerging challenges.
Methods: We used data from the Global Burden of Disease 2021, analyzing prevalence, incidence, and disability-adjusted life years (DALYs) of MD from 1990 to 2021.
Background: Lung cancer has become the malignant tumor with the highest morbidity and mortality in the world. This study aims to analyze the burden of lung cancer and risk factors associated with lung cancer in the BRICS from 1990-2021 and to project the burden of lung cancer in the BRICS from 2021-2035.
Methods: The Global Burden of Disease (GBD) 2021 database was searched to collect the incidence, prevalence, mortality, disability-adjusted life years (DALYs), and risk factors of lung cancer in the BRICS.
Burden trends and future predictions for hypertensive heart disease attributable to non-optimal temperatures in the older adults amidst climate change, 1990-2021.
Front Public Health
January 2025
Department of Cardiac Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Background: Hypertensive heart disease (HHD) is a significant form of end-organ damage caused by hypertension, with profound impacts on global health and quality of life. Temperature anomalies driven by climate change, particularly extremes of heat and cold, are increasingly recognized as major contributors to the cardiovascular disease burden, notably impacting HHD. However, the specific spatiotemporal trends and gender-based differences in the burden of non-optimal temperatures on older adults HHD patients remain insufficiently explored.
View Article and Find Full Text PDF[Impact of premature deaths from malignant tumors on life expectancy among Chinese residents, 1990-2021].
Zhonghua Liu Xing Bing Xue Za Zhi
January 2025
National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing100050, China.
To analyze premature deaths from malignant tumors among Chinese residents from 1990 to 2021, and to quantify the extent to which changes in premature mortality from malignant tumors affect life expectancy among people aged 30 to 69 years. Using the Global Burden of Disease 2021 data on selected causes of death in China, the malignant tumor mortality rate was estimated for Chinese residents aged 30-69 years from 1990 to 2021, and life expectancy and de-malignant cause-of-death life expectancy were calculated based on the abridged life table for the Chinese population. Arriaga's decomposition method was used to assess the extent to which changes in malignant tumors mortality contributed to changes in life expectancy for people aged 30-69 years and Potential gains in life expectancy (PGLEs) for people aged 30- 69 years.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!