AI Article Synopsis
- The study presents a simple method for creating spiro-γ-lactams that have both seven- and five-membered rings using a multicomponent reaction that involves glycine.
- Four different spiro-γ-lactams were analyzed, including some characterized through X-ray diffraction, indicating they are unstable intermediates from the Strecker degradation process.
- The research explored this previously unknown reaction pathway using mass spectrometry, which helped outline a possible mechanism for the reaction.
Article Abstract
A facile route to spiro-γ-lactams containing fused seven- and five-membered rings is showcased here in a multicomponent reaction harnessing glycine. Four spiro-γ-lactams were characterised, including by X-ray diffraction techniques, showing them to be trapped unstable intermediates of the Strecker degradation. This hitherto unknown reaction pathway was investigated with mass spectrometry, revealing a plausible reaction mechanism.
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| http://dx.doi.org/10.1039/d4ob01719f | DOI Listing |
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