The objective of this study was to assess the safety and describe treatment details of prolonged magnesium sulfate (MgSO ) infusion for children with asthma exacerbation. A retrospective cross-sectional study included children under 13 years of age who were admitted with asthma exacerbation and received at least 24 hours of MgSO infusion. One hundred children were included. No patients developed serious adverse events. The mean infusion duration was 74.2 hours. Eighty-nine percent recovered with no other bronchodilator infusions, and 94% did not require respiratory support escalation. Prolonged MgSO infusion is safe at a maximum dose of 30 mg/kg/h and may be beneficial for children with asthma exacerbation.
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http://dx.doi.org/10.1055/s-0042-1742674 | DOI Listing |
Front Vet Sci
October 2024
School of Bioscience and Veterinary Medicine, University of Camerino, Camerino, Italy.
Introduction: Magnesium Sulphate (MgSO) is commonly used in human medicine for the management of perioperative pain in different types of procedures. However, in veterinary medicine, the use of MgSO has not been evaluated for its analgesic efficacy in dogs, which has generated conflicts of opinion in this area of veterinary anesthesiology. The aim of this study was to evaluate the perioperative analgesic efficacy of MgSO in combination with Ketamine in dogs undergoing Tibial Plateau Leveling Osteotomy (TPLO).
View Article and Find Full Text PDFVet Anaesth Analg
October 2024
Department of Veterinary Medicine, Center for Agro-Veterinary Sciences (CAV), Santa Catarina State University (UDESC), Lages, Santa Catarina, Brazil.
Objective: To evaluate cardiopulmonary, arterial blood gas and propofol-sparing effects of magnesium sulfate (MgSO) constant rate infusion (CRI) in mechanically ventilated dogs maintained under total intravenous anesthesia with propofol.
Study Design: Blinded, randomized, clinical trial.
Animals: A total of 24 healthy adult dogs.
J Subst Use Addict Treat
May 2024
Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
Introduction: Precipitated opioid withdrawal syndrome (OWS) is a severe and intolerable situation that may occur by a pharmaceutical agent. Reactivation of inhibited N-methyl-d-aspartate (NMDA) receptor in person with prolonged opioid use can led to severe OWS. We conducted a double-blind, randomized clinical trial to assess the effect of magnesium sulfate (MGSO) as an NMDA receptor antagonist on OWS.
View Article and Find Full Text PDFPaediatr Anaesth
May 2024
Intensive Care, and Pain Management, Kasr Al Aini Hospital, Cairo University, Cairo, Egypt.
Background: Junctional ectopic tachycardia (JET) is a serious tachyarrhythmia following pediatric cardiac surgery. It isn't easy to treat and better to be prevented. This study aimed to examine the prophylactic effects of dexmedetomidine, MgSO, or their combination in reducing JET following pediatric open cardiac surgery.
View Article and Find Full Text PDFArch Gynecol Obstet
July 2024
Department of Obstetrics and Gynecology, Pusan National University School of Medicine, 179 Gudeck-Ro, Seo-gu, Busan, 49241, Republic of Korea.
Purpose: To investigate the effect of intravenous MgSO on maternal cerebral hemodynamics as well as the association between altered Doppler indices of the ophthalmic arteries and ocular lesions in patients with preeclampsia.
Methods: After each of the 15 included patients was diagnosed with preeclampsia, MgSO was infused followed by transcranial Doppler tests of the indices of the ophthalmic, anterior, middle, posterior cerebral, vertebral, and basilar arteries, followed by a second MgSO infusion. The peak, mean, diastolic velocity, and pulsatile and resistance indices of each artery were automatically measured during testing.
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