AI Article Synopsis
- The discovery of the CRISPR-Cas system emphasizes that we still have a lot to learn about how bacteria and archaea defend against viruses.
- Researchers are continuously finding new immune systems in prokaryotes, which adds to our understanding of viral defense.
- A recent study identified a new enzyme (glycosylase) that targets a specific modified base in the T4 phage genome, preventing the virus from replicating by creating an abasic site.
Article Abstract
The recent discovery of the CRISPR-Cas-mediated acquired immunity system highlights the fact that our knowledge of phage/virus defense mechanisms encoded in bacterial and archaeal genomes is far from complete. Indeed, new prokaryotic immune systems are now continually being discovered. A recent report described a novel glycosylase that recognizes α-glycosyl-hydroxymethyl cytosin (α-Glu-hmC), a modified base observed in the T4 phage genome, where it produces an abasic site, thereby inhibiting the phage propagation.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611026 | PMC |
| http://dx.doi.org/10.1016/j.engmic.2024.100153 | DOI Listing |
Publication Analysis
Top Keywords
novel strategy
4
strategy protect
4
protect prokaryotic
4
prokaryotic cells
4
cells virus
4
virus infection
4
infection discovery
4
discovery crispr-cas-mediated
4
crispr-cas-mediated acquired
4
acquired immunity
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!