AI Article Synopsis
- Nightmares and flashbacks are common symptoms of PTSD that can severely affect daily life.
- Prazosin is often used off-label to treat these symptoms, but its short half-life requires multiple doses throughout the day.
- Doxazosin shows promise as an alternative treatment for PTSD-related nightmares, with a longer half-life and fewer side effects, as demonstrated in three patient cases after prazosin was stopped.
Article Abstract
Nightmares and flashbacks are common debilitating symptoms of posttraumatic stress disorder (PTSD) that can disrupt daily functioning. Prazosin, an alpha-1 adrenergic antagonist, has been commonly used off-label for the treatment of these intrusion symptoms, although its short half-life makes it so that often multiple doses are needed. Doxazosin, another alpha-1 antagonist, is starting to be investigated in the treatment of PTSD-related nightmares due to its lesser side effect profile and longer half-life. In our case series, we present three cases of patients with PTSD-related nightmares who were successfully treated with doxazosin following a relapse of symptoms after discontinuation of prazosin for various reasons. The success of doxazosin immediate release for PTSD-related nightmares warrants further studies into its efficacy and use as an alternative treatment to prazosin.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614496 | PMC |
| http://dx.doi.org/10.1155/crps/6452923 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Doxazosin Immediate Release as a Novel Treatment for Nightmares in Posttraumatic Stress Disorder.
Case Rep Psychiatry
November 2024
Department of Psychiatry, Rowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey, USA.
Article Synopsis
- Nightmares and flashbacks are common symptoms of PTSD that can severely affect daily life.
- Prazosin is often used off-label to treat these symptoms, but its short half-life requires multiple doses throughout the day.
- Doxazosin shows promise as an alternative treatment for PTSD-related nightmares, with a longer half-life and fewer side effects, as demonstrated in three patient cases after prazosin was stopped.
The similarities and differences of network structures of posttraumatic stress symptoms among Chinese adolescents exposed to three different types of trauma.
Psychol Trauma
June 2024
Department of Health Policy and Management, School of Public Health, Peking University Health Science Center.
Article Synopsis
- The study investigates how PTSD symptoms are structured in adolescents who have experienced different types of trauma, including accidents, natural disasters, and severe diseases.
- A total of 2,234 traumatized students were analyzed to compare the PTSD symptom networks across these trauma types.
- Key findings indicated that negative emotional symptoms are central across all trauma types, with unique symptom connections observed, particularly in the accident exposure group, highlighting the need for future research on trauma-related emotions in PTSD.
Comparison of alpha-2 agonist versus alpha-1 antagonist for post-traumatic stress disorder-associated nightmares in pediatric patients.
Ment Health Clin
June 2024
Child and Adolescent Psychiatrist, Virginia Commonwealth University Health System Department of Psychiatry, Division of Child and Adolescent Psychiatry, Richmond, Virginia.
Introduction: Posttraumatic stress disorder (PTSD) in children and adolescents has a high prevalence of accompanying sleep disturbances. Currently, pediatric treatment of PTSD-related nightmares is extrapolated from adult studies. This study aims to determine the effectiveness and safety of clonidine and guanfacine compared with prazosin for the treatment of PTSD-related nightmares.
View Article and Find Full Text PDFA Retrospective Pilot Study of Imagery Rehearsal Therapy Enhanced with Narrative Therapy Principles for the Treatment of Nightmares in US Military Veterans.
Sleep Sci
December 2023
Pulmonary, Allergy, Critical Care and Sleep, Minneapolis Veteran's Affairs (VA) Health Care System, Minneapolis, MN, United States of America.
Chronic nightmares are a common and disabling feature of posttraumatic stress disorder (PTSD) for which broadly effective treatments are still lacking. While imagery rehearsal therapy (IRT) demonstrates benefits for patients with idiopathic nightmares and some patients with PTSD-related nightmares, research indicates it may be less beneficial for veterans. Narrative therapy (NT) is a form of psychotherapy which is client-centered and value-focused and has demonstrated benefits for PTSD patients.
View Article and Find Full Text PDFA Pilot Study on the Effectiveness of Prazosin as a Treatment of Post-Traumatic Stress Disorder-Related Nightmares in Women with Bulimia Nervosa.
Cureus
July 2023
Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, USA.
Objectives Post-traumatic stress disorder (PTSD) symptoms are reported in over 36% of individuals with bulimia nervosa. To date, none of the clinical trials have examined nightmare reduction in this population. We evaluated the effectiveness of prazosin in bulimic females experiencing PTSD-related nightmares.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!