AI Article Synopsis
- Sexual reproduction, while beneficial for creating offspring, comes with significant costs and challenges, particularly during pregnancy.* -
- Autophagy, a vital process controlled by specific genes, plays a key role in managing metabolic stress throughout pregnancy in viviparous eukaryotes.* -
- The review highlights the importance of autophagy in reproduction and its potential impact on pregnancy disorders like preterm birth and preeclampsia, suggesting it could be a target for future therapies.*
Article Abstract
As advantageous as sexual reproduction is during progeny generation, it is also an expensive and treacherous reproductive strategy. The viviparous eukaryote has evolved to survive stress before, during, and after pregnancy. An important and conserved intracellular pathway for the control of metabolic stress is autophagy. The autophagy process occurs in multiple stages through the coordinated action of autophagy-related genes. This review summarizes the evidence that autophagy is an integral component of reproduction. Additionally, we discuss emerging techniques that will enable cellular and molecular studies of autophagy and its associated pathways in reproduction. Finally, we discuss the role of autophagy in the pathogenesis and progression of several pregnancy-related disorders such as preterm birth, preeclampsia, and intra-uterine growth restriction, and its potential as a therapeutic target.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613427 | PMC |
| http://dx.doi.org/10.1016/j.isci.2024.111268 | DOI Listing |
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