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The gut microbiota confers resistance against Typhimurium in cockroaches by modulating innate immunity. | LitMetric

The gut microbiota confers resistance against Typhimurium in cockroaches by modulating innate immunity.

iScience

University of South Dakota, Sanford School of Medicine, Division of Basic Biomedical Sciences, Vermillion, SD, USA.

Published: December 2024

AI Article Synopsis

  • Cockroaches show varying levels of susceptibility to Typhimurium infection, and their gut microbiota plays a key protective role against this colonization.
  • Research indicates that the presence of commensal bacteria in the gut does not directly compete with Typhimurium but helps activate the cockroach's defenses by boosting antimicrobial peptide production.
  • The study reveals that specific minority bacterial species, rather than the overall number or diversity of gut bacteria, are important for understanding infection susceptibility, highlighting cockroaches as a potential model for studying microbial interactions and reducing disease spread.

Article Abstract

Cockroaches exhibit unexplained intra- and interpopulation variation in susceptibility to serovar Typhimurium ( Typhimurium) infection. Here, we show that the gut microbiota has a protective effect against colonization by ingested Typhimurium in cockroaches. We further examine two potential mechanisms for this effect, showing that commensal bacteria present in the gut do not compete with Typhimurium during growth in cockroach feces, but rather prime expression of host antimicrobial peptide genes that suppress Typhimurium infection. Lastly, we determine that neither absolute abundance of the microbiota nor its overall diversity is linked to infection susceptibility. Instead, we identify several minority bacterial taxa that exhibit interindividual variation in abundance as key indicators of infection susceptibility among genetically similar individuals. These findings illuminate the potential of cockroaches as an invertebrate model for interspecies microbial interactions and provide insight into vector-borne transmission, suggesting that the microbiota of cockroaches could be targeted to reduce pathogen transmission.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612784PMC
http://dx.doi.org/10.1016/j.isci.2024.111293DOI Listing

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