Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11612744 | PMC |
| http://dx.doi.org/10.4081/dr.2024.9827 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Reproducibility and repeatability of 18F-(2S, 4R)-4-fluoroglutamine PET imaging in preclinical oncology models.
PLoS One
January 2025
Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United States of America.
Introduction: Measurement of repeatability and reproducibility (R&R) is necessary to realize the full potential of positron emission tomography (PET). Several studies have evaluated the reproducibility of PET using 18F-FDG, the most common PET tracer used in oncology, but similar studies using other PET tracers are scarce. Even fewer assess agreement and R&R with statistical methods designed explicitly for the task.
View Article and Find Full Text PDFThe NSD-ISS Working Group developed a data-driven approach to: 1) determine a biologic definition for disease; 2) establish a framework for a disease staging platform. NSD is defined by the presence of pathologic n-asyn (S) assessed by a validated in vivo biomarker and ultimate presence of dopaminergic neuronal dysfunction (D). This biologic definition is independent of the presence of clinical features, or if present, of the specific clinical syndrome.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Siemens Medical Solutions USA, Inc., Molecular Imaging, Knoxville, TN, USA.
Background: 18F-flortaucipir allows in-vivo visualization of tau tangles in Alzheimer's disease (AD) with a standardized definition of tau-PET positivity. However, semi-quantification is often used in research and in therapeutic trials and plays an important role in the AT(N) framework. This work aims to determine quantitative positivity thresholds and compare semi-quantification to visual interpretation.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Background: Glymphatic clearance dysfunction within the perivascular space has been implicated in Alzheimer's Disease (AD) pathology. Diffusion MRI-based techniques such as DTI-ALPS can quantify perivascular interstitial fluid (ISF) dynamics, yet their links with other early AD markers in the cognitively normal elderly population remain underexplored. Here, we investigated associations between DTI-ALPS and cerebral β-amyloid (Aβ) burden measured with Pittsburgh Compound B (PiB)-PET.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Mallinckrodt Institute of Radiology, Washington University School of Medicine in St Louis, St Louis, MO, USA.
Background: Application of the amyloid/tau/neurodegeneration (ATN) framework is varied, with some research relying on binary assessment of biomarkers and some using continuous or multidimensional measures. There are few investigations which directly evaluate how differing operationalizations of ATN affect prediction of cognitive impairment.
Method: We selected 473 individuals from ADNI who received PET imaging for amyloid-beta (AV-45) and tau (flortaucipir), as well as volumetric MRI.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!