AI Article Synopsis

  • Hypogammaglobulinemia, a condition of low immunoglobulin levels, is common in newly diagnosed diffuse large B cell lymphoma (DLBCL) patients and is linked to worse overall survival outcomes.
  • A study analyzed data from 585 DLBCL patients in Southern Sweden, revealing that 24% had hypogammaglobulinemia at baseline, particularly affecting IgG levels the most.
  • The research found that patients with low Ig levels experienced more infections during treatment, indicating that hypogammaglobulinemia significantly impacts treatment complications and prognosis.

Article Abstract

There are some evidences that hypogammaglobulinemia in newly diagnosed diffuse large B cell lymphoma (DLBCL) is a predictor for inferior outcome, but the risk for infection-related admissions specifically related to hypogammaglobulinemia is not known. The aim was to explore if hypogammaglobulinemia in untreated DLBCL in a Swedish cohort was associated with inferior outcome, and to assess the relationship between low immunoglobulin (Ig) levels and infections. Using data from the Swedish Lymphoma Register, we retrospectively identified patients above18 years diagnosed with DLBCL, receiving anthracycline-based curative therapy during 2000-2015 in Southern Sweden with Ig-levels tested at baseline. Data on Ig levels and infections were collected from medical records. Five hundred eighty-five patients were included, median age was 69 years. Hypogammaglobulinemia was detected at baseline in 24%, the most common Ig deficiency was IgG (18%), followed by IgA (10%) and IgM (8%). Hypogammaglobulinemia was associated with inferior overall survival (HR 1.4, 95% CI 1.0-1.8, p-value 0.018), but not when adjusted for International Prognostic Index (IPI). Low levels of Ig were associated with more infections during lymphoma treatment (p-value 0.013), also when adjusted for IPI (p-value < 0.001). Among patients with IgG deficiency, 47% had ≥ 1 infections versus 35% in patients with normal IgG (HR 1.2, p = 0.025). In conclusion, hypogammaglobulinemia was a frequent finding in patients with newly diagnosed DLBCL, with clinical impact in terms of treatment complications and outcome.

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Source
http://dx.doi.org/10.1002/hon.70014DOI Listing

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