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No association between two candidate markers of prenatal sex hormones: digit ratios (2D:4D and other) and finger-ridge counts.

Dev Psychobiol

January 2011

Department of Basic Psychological Research, School of Psychology, University of Vienna, Liebiggasse 5, Vienna, Austria.

The second-to-fourth digit ratio (2D:4D), putatively indexing prenatal androgen levels retrospectively, has become increasingly popular as an easily applied measure in research into the prenatal sex-hormonal bases of behavior, health, and disease. However, its validity has not yet been conclusively demonstrated and in fact is currently debated, because validation tests of 2D:4D with other, prenatally established, presumed markers for prenatal sex-hormone action have yielded mixed evidence or still are unavailable. Hence, the associations of 2D:4D with finger-ridge counts, one such further under-researched marker, were examined in this study.

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Prenatal sex hormone effects on child and adult sex-typed behavior: methods and findings.

Neurosci Biobehav Rev

April 2005

Department of Child and Adolescent Psychiatry, and Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands.

There is now good evidence that human sex-typed behavior is influenced by sex hormones that are present during prenatal development, confirming studies in other mammalian species. Most of the evidence comes from clinical populations, in which prenatal hormone exposure is atypical for a person's sex, but there is increasing evidence from the normal population for the importance of prenatal hormones. In this paper, we briefly review the evidence, focusing attention on the methods used to study behavioral effects of prenatal hormones.

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Dermatoglyphics in 46, XY females.

J Indian Med Assoc

August 2001

Department of Anatomy, St. John's Medical College, Bangalore.

Dermatoglyphics is known to be one of the best available diagnostic tools in genetic disorders. This paper aims to find out the diagnostic characteristic dermatoglyphic features in cytogenetically confirmed 46, XY female patients. The total number of patients studied (46, XY females) were 31 and the control consisted of 30 males and 30 females.

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The dermatoglyphic pattern of dermal ridges that constitutes the human fingerprint is complete by the 16th foetal week and its development is thought to be influenced by prenatal hormones. Finger ridge count (FRC) is asymmetrical with the majority having more ridges on the finger tips of the right hand (R >) while the minority have more on the left (L >). In adults, the R > condition has been associated with male-typical, and the L > condition with female-typical, performance on sexually dimorphic tasks.

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It has been proposed that gender identity and sexual orientation are influenced by the prenatal sex steroid milieu. Human dermatoglyphics and brain asymmetry have also been ascribed to prenatal hormone levels. This study investigated dermatoglyphics (total ridge count and finger ridge asymmetry) in 184 male-to-female transsexuals and 110 female-to-male transsexuals.

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