AI Article Synopsis
- A phase 1 study investigated the safety and feasibility of transplanting spinal cord-derived neural stem cells (NSI-566) for chronic spinal cord injuries, focusing on four participants with specific injuries.
- All participants tolerated the stem cell procedure well without major complications.
- After five years, two participants showed significant neurological improvements, with measurable gains in motor and sensory functions.
Article Abstract
We report the long-term results for a phase 1 study of neural stem cell transplantation for chronic spinal cord injury. The trial was registered on ClinicalTrials.gov as NCT01772810. The primary outcome of the trial was to test the feasibility and safety of human spinal cord-derived neural stem cell (NSI-566) transplantation for the treatment of chronic spinal cord injury in four subjects with thoracic two to thoracic twelve spinal cord injury. Here, we report that all four subjects tolerated the stem cell implantation procedure well, and two subjects had durable electromyography-quantifiable evidence of neurological improvement as well as increased neurological motor and sensory scores at five years post-transplantation.
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| http://dx.doi.org/10.1016/j.xcrm.2024.101841 | DOI Listing |
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